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Artigo em Inglês | IMSEAR | ID: sea-170320
2.
Artigo em Inglês | IMSEAR | ID: sea-158470

RESUMO

Background & objectives: Early identification of bacterial infection in patients with fever is important for prompt treatment. However, the available parameters such as C-reactive protein (CRP) and leukocyte counts are not very specific. This study was aimed to assess the diagnostic value of procalcitonin (PCT), CRP, interleukin-6 (IL-6) and serum amyloid A (SAA) for bacterial infection in febrile patients. Methods: Serum samples were collected from febrile patients between January and December 2012 and processed for blood cultures. PCT, IL-6, CRP and SAA levels were measured. The patients were divided into three groups according to the final diagnosis: bacteraemia group (group1), bacterial infection with negative blood culture (group 2) and non-bacterial infection group (group 3). Results: There were significant (P<0.05) difference in the levels of PCT, CRP, IL-6 and SAA among the three groups. The PCT levels of patients with gram-positive bacterial infections were lower than gram-negative bacterial infections (0.53 vs 2.13, P < 0.01). The best cut-off value to detect bacterial infections was 0.26 ng/ml for PCT. PCT, CRP, IL-6 and SAA had areas under the curve of 0.804, 0.693, 0.658 and 0.687, respectively. Interpretation & conclusions: Our results showed PCT as a valuable marker of bacterial infections in febrile patients. PCT was superior to CRP, IL-6 or SAA in the early identification of bacterial infection. More prospective and large scale studies are warranted to confirm these findings.


Assuntos
Infecções Bacterianas/complicações , Infecções Bacterianas/diagnóstico , Biomarcadores/análise , Biomarcadores/sangue , Proteína C-Reativa/análise , Proteína C-Reativa/sangue , Calcitonina/análise , Calcitonina/sangue , Febre/diagnóstico , Febre/etiologia , Humanos , Interleucina-6/análise , Interleucina-6/sangue , Precursores de Proteínas/análise , Precursores de Proteínas/sangue , Proteína Amiloide A Sérica/análise , Proteína Amiloide A Sérica/sangue
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