Sign of Leser-Trelat: a paraneoplastic sign of internal malignancy

A 63-year-old female presented with dark brown hyperpigmented macules and slightly elevated papules all over body, clinically and histopathologically suggestive of seborrhoeic keratosis. She was diagnosed as breast carcinoma 5 years back and got mastectomy done 2 years back. Cutaneous lesions appeared 6 months before the diagnosis of breast carcinoma and remained static after mastectomy, thus fulfilling some of the Curth's criteria for the diagnosis of paraneoplastic syndrome. Till date there is only one report of Leser-Trelat sign with associated carcinoma of breast. We are reporting Leser-Trelat as a paraneoplastic phenomenon secondary to invasive ductal breast carcinoma for its rarity and the classical clinicopathological evidence

Atrophia maculosa varioliformis cutis - a rare case report

We present a 4-year-old girl with a 3-year history of spontaneous atrophic lesions of variable shape and size over face. There was no history of trauma, seasonal variation, photosensitivity or presence of inflammatory lesions preceding the development of atrophic lesions over the facial skin. Lesions were increasing in number gradually and spontaneously. Family history was insignificant. On examination sharply defined varioliform lesions i.e. oval, linear and small circular atrophic macules were evident on cheeks, nose and forehead with normal surrounding facial skin. Histopathological examination revealed mild elastic fibre degeneration in dermis. Clinical history, cutaneous and histopathological findings of our case fits in to the description of atrophia maculosa varioliformis cutis

Epidemiology and risk analysis of malaria among pregnant women

Malaria remains a complex problem during the pregnancy, which threatens > 35 millions pregnant women every year. Malaria pathogenesis in pregnancy results in accumulation of infected RBCs in the intervillous spaces causing severe alterations leading to the reduced materno-foetal exchanges. In this article we have revisited the current evidences of clinical implications and overall burden of malaria in pregnancy. Many adverse aftermaths including, low birth weight, intrauterine growth retardation, preterm delivery, stillbirth and anemia were found associated with malaria in pregnant women. Despite of worldwide comprehensive control programmes for malaria in pregnancy, the disease control has been a daunting task everywhere. Socio cultural, economical, lack of awareness and various logistic problems compound the disease in developing countries. Thorough evidence based information and estimates, education and awareness and strengthening of prevention programmes are needed urgently to achieve success in malaria control in pregnancy