Nautral coagulation inhibitors in coronary heart disease [CHD]

Haemostasis may be implicated in the pathogenesis of various thrombotic disease. Assay of natural coagulation inhibitors [AT III and PC] in coronary heart diseases may be informative in such cases. In this work, AT III and PC were assayed for 23 patients with coronary ischaemia and infarction besides 12 controls. A highly significant reduction in AT III had been observed in patient groups which had been attributed to an activated coagulation mechanism with consequent consumption of AT III. On the other hand, a significant increase in PC activity had been observed in both studied groups. This rise may be a body attempt to overcome hypercoagulability in those patients. We recommend a trial to use AT III and recombinant APC as therapeutic lines in patients with coronary heart diseases

Blood level of vitamin A, ascorbic acid and folate in hemophilic patients

The target of this work was to search for any relation between the nutritional status and haemophilia and whether the disease alters the level of certain vitamins. Therefore, serum vitamin A, plasma ascorbic acid, serum and red cell folate had been determined in 23 haemophilic patients together with 16 normal control persons. From the forementioned discussion, we concluded that there was a significant haemophilics despite their dietary vitamin C intake was in excess of 66% of RAD. Meanwhile, the demands for ascorbic acid needed for tissue repair in haemophilic patients could be reduced with prompt medical care of bleeding episodes and optimal nutritional care. A non significant differences had been observed in the serum vitamin A, red cell and serum folate in haemophilic patients as compared to control subjects

relevance of protein C and antithrombin III in Diabetes mellitus

Protein C-a natural coagulation inhibitor is activated by thrombin. It cleaves off an NH2 terminal activation peptide. Many investigators reported that PC has been incriminated in hypercoagulability state in diabetic patients. This induced us to study PC activity and AT III concentration in this disease. We investigated 18 diabetic patients. On oral hypoglycemic therapy for PC activity and AT III concentration and compared their results those of 10 selected healthy control subjects. A highly significant reduction was found in both studied parameters in the diabetic group. These findings stress the major role of hyperglycemia in determining PC reduction in diabetics, and suggest that PC reduction probably associated to hyperglycemia enhanced thrombin formation

Serum, ascitic fluid and urinary biochemical changes in bilharzial patients with refractory ascites

15 ascites patients with aepatosplenic bilharziasis responding to diuretic therapy were taken as control group. 20 patients with bilharzial hepatosplenic affection and retraciory ascites were the material of the present study. All patients from both groups were subjected to investigations to prove pure bilharzial etiology. In their serum, and serum and ascitic fluid enzymes [GOT, G.P.T., Alkaline phosphatase and L.D.H.], Proteins [Albumin total globulin, Alpha[1], Alpha[2] Beta and Gamma globulin]; glucose, cholestrol, bilirubin [total and direct], B.U.N., creatinine and electrolytes [Phosphorus, calicum, pottassium, sodium and chloride] were assessed. Urinary electrolytes [Phosphorus, calcium, calcium potassium, sodium and chlorid] were also meadured for all. The serum biochemical data of patients with refractory ascites showed that they were in a more advanced stage of hepatocellular damage than patients with non refractory ascitis. The ascitographic picture of biochemical data of both groups showed selective significant differences that can be taken as a parameters to fortell refractoriness of ascites during the follow up of cases in the course of that disease. Selective significant differences in urinary electrolytes of both groups can also be taken as forerunnex to predict refractoriness of ascites. The A/S ratio of different biochemical data in both groups showed selective significant differences that can be taken as a parameters for detection of the impending refractory ascitic stage in the course of bilharzial hepatosplenic affection. The concept of an active role for the peritoneum in ascitogrophic biochemical patterns construction was proposed and discussed