RESUMO
A 48 years old man presented with subacute intestinal obstruction resulting from an intraluminal colorectal mass. He underwent partial colectomy. Histological diagnosis of mucinous adenocarcinoma with focal areas of heterotopic ossification was made. Although the presence of heterotopic ossification has no known prognostic implication in colorectal carcinoma, however, it is important that both radiologist and pathologist be aware of this phenomenon as distinct from carcinosarcoma that has poorer prognosis. From the available literature reviewed and to the best of our knowledge, this is the first reported case of mucinous colorectal carcinoma with heterotopic ossification in Saudi Arabia
RESUMO
This study examined the expression of transforming growth factor-beta [TGF-beta] in psoriatic as well as normal skin to elucidate its potential involvement in the pathogenesis of psoriasis and to find out the relation between disease severity and its local expression in the skin. When compared with normal skin, TGF-beta expression was absent or diminished in the epidermis of psoriatic lesions which was more evident in the lower epidermis. Both normal and psoriatic specimens showed minimally detectable TGF-beta in the dermis. A statistically significant correlation was found between TGF-beta expression in the epidermis and disease severity [PASI score]. The result suggested that the lack or diminished TGF-beta-mediated growth inhibition may play an important role in the pathogenesis of psoriasis