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1.
Pediatric Gastroenterology, Hepatology & Nutrition ; : 197-206, 2021.
Artigo em Inglês | WPRIM | ID: wpr-903100

RESUMO

Purpose@#Celiac disease (CD) is a common autoimmune disease with extra-intestinal manifestations, including neurological disorders. There are few reports to assess various factors in increasing the chances of developing neurological disorders in CD, so we designed this study. @*Methods@#All patients with CD at any age who had been referred to the Celiac Clinic were evaluated for neurological problems. CD was defined as IgA anti-transglutaminase antibodies (anti-tTG) of 18 IU/mL or higher in serology and Marsh type I or more severe in histopathological evaluation. Logistic regression analysis was used to evaluate the impact of various independent variables on the neurological manifestations. @*Results@#A total of 540 patients enrolled in this study. A 360 (66.7%) of patients were children. A 64.8% and 35.2% were female and male, respectively. Overall, 34.1% of patients had neurological manifestation, including headache, neuropathy, epilepsy, and ataxia. The odds of developing neurological manifestations in children were significantly lower than in adults (odds ratio [OR], 0.66; 95% confidence interval [CI], 0.45–0.96; p=0.03) and in patients with gastrointestinal (GI) symptoms significantly higher than in the group without GI manifestations (OR, 1.77; 95% CI, 1.18–2.63; p=0.005). Other variables, including Marsh classification (OR, 0.44; 95% CI, 0.18– 1.11; p=0.08) and anti-tTG levels (OR, 1.00; 95% CI, 0.999–1.001; p=0.59) did not significantly increase the chances of developing neurological disorders. @*Conclusion@#Our study showed that increasing age and the presence of GI symptoms, but not serological and histological findings, could increase the chances of developing neurological diseases in CD patients.

2.
Pediatric Gastroenterology, Hepatology & Nutrition ; : 197-206, 2021.
Artigo em Inglês | WPRIM | ID: wpr-895396

RESUMO

Purpose@#Celiac disease (CD) is a common autoimmune disease with extra-intestinal manifestations, including neurological disorders. There are few reports to assess various factors in increasing the chances of developing neurological disorders in CD, so we designed this study. @*Methods@#All patients with CD at any age who had been referred to the Celiac Clinic were evaluated for neurological problems. CD was defined as IgA anti-transglutaminase antibodies (anti-tTG) of 18 IU/mL or higher in serology and Marsh type I or more severe in histopathological evaluation. Logistic regression analysis was used to evaluate the impact of various independent variables on the neurological manifestations. @*Results@#A total of 540 patients enrolled in this study. A 360 (66.7%) of patients were children. A 64.8% and 35.2% were female and male, respectively. Overall, 34.1% of patients had neurological manifestation, including headache, neuropathy, epilepsy, and ataxia. The odds of developing neurological manifestations in children were significantly lower than in adults (odds ratio [OR], 0.66; 95% confidence interval [CI], 0.45–0.96; p=0.03) and in patients with gastrointestinal (GI) symptoms significantly higher than in the group without GI manifestations (OR, 1.77; 95% CI, 1.18–2.63; p=0.005). Other variables, including Marsh classification (OR, 0.44; 95% CI, 0.18– 1.11; p=0.08) and anti-tTG levels (OR, 1.00; 95% CI, 0.999–1.001; p=0.59) did not significantly increase the chances of developing neurological disorders. @*Conclusion@#Our study showed that increasing age and the presence of GI symptoms, but not serological and histological findings, could increase the chances of developing neurological diseases in CD patients.

3.
IJMS-Iranian Journal of Medical Sciences. 2015; 40 (5): 465-468
em Inglês | IMEMR | ID: emr-174307

RESUMO

Fasciola hepatica [F. hepaticd] as a foodborne trematode can occasionally cause hepatobiliary diseases. We report a 67-year-old woman who was referred to our center because of the diagnosis of cholangitis. She was a resident of mountainous area with the history of unsafe water and contaminated vegetables. Endoscopic retrograde cholangiopancreatography [ERCP] was performed as a diagnostic and therapeutic modality for her. Three living R hepatica was removed from biliary tract with a basket via ERCP. Clinical and laboratory condition of the patient improved after therapy of antibiotics and triclabendazole

4.
TIPS-Trends in Pharmaceutical Sciences. 2015; 1 (2): 65-74
em Inglês | IMEMR | ID: emr-183121

RESUMO

Gastroesophageal reflux disease [GERD] is a very common disease. GERD is defined as the reflux of stomach content which causes troublesome symptoms and/or complications. The management of GERD is step by step. Dietary and lifestyle modifications are the first steps. Twice-daily H2RAs at standard doses for a minimum duration of two weeks can be considered in patients with GERD who fail to respond to lifestyle and dietary modifications. If symptoms of GERD persist, once-daily Proton Pump Inhibitors [PPIs] can be recommended. Patients with an unsatisfactory response to once-daily PPIs dosing can be considered to have refractory GERD. Twice-daily PPI therapy can be recommended in patients who fail to respond to once-daily PPI therapy. The add-on treatment with H2RAs, baclofen, or visceral pain modulators can be considered in selective subjects with GERD who fail to respond to twice daily PPI. Anti-reflux surgery may be taken into account in selected patients. This review focuses on the initial and maintenance therapy of GERD and also reviews different management of recurrent and refractory GERD

5.
Middle East Journal of Digestive Diseases. 2015; 7 (2): 100-103
em Inglês | IMEMR | ID: emr-166788

RESUMO

Although complicated acute appendicitis is occasionally observed in general practice, the diagnosis of appendiceal abscess by colonoscopy is unusual. We report a case of appendiceal abscess with spontaneous drainage into the lumen of colon diagnosed during colonoscopy and resolved by the time of surgery


Assuntos
Humanos , Masculino , Colonoscopia , Literatura de Revisão como Assunto , Apêndice , Doenças do Ceco
6.
TIPS-Trends in Pharmaceutical Sciences. 2015; 1 (4): 235-242
em Inglês | IMEMR | ID: emr-188378

RESUMO

Metronidazole is a main stay of modern multidrug therapies for Helicobacter pylori [H. pylori] infection. Metronidazole resistance reduces the effectiveness of these combination therapies. Various methods have been used for the determination of the sensitivity of H. pylori to metronidazole, that have shown conflicting results. The aims of this study are: 1] Comaring E-Test and disk diffusion methods for determining the susceptibility of H. pylori to metronidazole; and 2] As metronidazole resistance in H. pylori has been found to be associated with mutations in rdxA, the role of this gene in metronidazole resistance in H. pylori has been examined in this study. A total of 46 H. pylori strains from 223 consecutive patients were examined. The E-Test was performed according to the manufacturer's guidelines, and the disk diffusion test, according to standard procedure, using 5 micro g metronidazole disks. Extraction of DNA was done from all H. pylori isolates by boiling and the use of phenol-chloroform methods, and afterwards Polymerase Chain Reaction [PCR] was performed. Metronidazole resistance as determined by E-test and disk diffusion methods, was 64.3% and 47.6% respectively. None of the resistant or sensitive samples possessed rdxA gene deletion. Disk diffusion method is not reliable in determining metronidazole resistance in H. pylori. An intact rdxA gene has also been reported in metronidazole-resistant H. pylori, suggesting that additional metronidazole resistance mechanisms exist in H. pylori and even molecular methods are not reliable for the detection of this resistance

7.
Acta Medica Iranica. 2013; 51 (12): 910-912
em Inglês | IMEMR | ID: emr-148296

RESUMO

Acute cholangitis [AC] is commonly observed in general practice with different causes. We report a case of recurrent AC caused by anomaly of the right hepatic artery, as a rare underlying condition

8.
Archives of Iranian Medicine. 2012; 15 (3): 177-178
em Inglês | IMEMR | ID: emr-116992

RESUMO

Although foreign body [FB] ingestion is relatively common,ingestion of a toothbrush is rare. We are reporting on a 26-year old female who had accidentally swallowed a toothbrush which was successfully removed via endoscopy using a polypectomy snare

9.
Acta Medica Iranica. 2011; 49 (9): 633-636
em Inglês | IMEMR | ID: emr-113962

RESUMO

Although gastrointestinal bleeding is common, hemobilia due to the rupture of hepatic artery pseudoaneurysm is uncommon. We report a case of hemobilia which was successfully treated via angiography


Assuntos
Humanos , Feminino , Artéria Hepática , Falso Aneurisma , Angiografia , Ruptura Espontânea , Endoscopia do Sistema Digestório , Embolização Terapêutica
10.
Middle East Journal of Digestive Diseases. 2011; 3 (2): 131-133
em Inglês | IMEMR | ID: emr-132073

RESUMO

Gastrointestinal melanoma [GIM] is occasionally observed in general practice. We report a case of melanoma dispersed diffusely in the stomach and duodenum with no skin involvement

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