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Introduction: In conditions like significant burns,traumatic injuries or an abdominal infection succinylcholineadministration could be hazardous as it is associatedwith dangerous hyperkalemia. Vecuronium, atracuriumand Pancuronium not only are the alternatives but alsooffer skeletal muscle relaxation at shortest intervals postintubation. We assessed the intubating conditions achievedand the hemodynamic effects of pancuronium, vecuronium,and atracurium among patients undergoing routine surgicalprocedures requiring general anaesthesia.Material and methods: A prospective randomized trial wascarried out among 60 participants aged 15-56, who were inthe good physical condition and belonged to ASA I or ASAII categories.study was conducted at Civil Hospital, AizawlMizoram. The patients were randomly allocated to 3 groups oftwenty each viz, Group A, Group B and Group C. Followinginduction of anaesthesia Inj. Pancuronium bromide 0.1 mg/kg.was given to Group A; Inj. Vecuronium 0.1 mg/kg to GroupB. and Inj. Atracurium 0.6 mg/kg to Group C. Pulse rate andblood pressure were recorded immediately and time intervalafter intubation.Results: The apnoea time was longest in group A (57±7seconds) followed by group C (50±14 seconds) and groupB (49±8 seconds). The mean pulse rate, however, variedsignificantly post-intubation across the three groups. Theintergroup comparison showed a significantly higher rise ofthe mean arterial pressure in group A compared with group Bat all corresponding tie intervals in the post intubation period.Conclusion: Though all the three skeletal muscle relaxantsprovided adequate intubating conditions, Vecuronium offeredthe shortest intubation time while the Pancuronium took thelongest time.
RESUMO
Introduction: Midazolam, a water-soluble benzodiazepine, isnon-irritant on intravenous injection and has a shorter durationof action than diazepam. In this research, we evaluated theinduction time achieved with midazolam and compared withthiopentone. We also observed the hemodynamic effectsfollowing induction with midazolam and thiopentone. In thecurrent study, we also studied undesirable or unwanted effectsof the two drugs.Material and methods: The present study was conductedat Civil Hospital, Aizawl Mizoram in thedepartmentofAnaesthesiology and Critical Care. The study was conductedbetween November 2018 to October 2019. A clinical studywas carried out in hundred patients with a physical status ofASA I and ASA II patients, patients between 20-50 years ofage and weight 45-70 kg were selected and were divided intotwo groups each group consisting of fifty patients. Group A– Midazolam (0.2mg/kg) and Group B – Thiopentone (5mg/kg). A routine preanaesthetic check-up was carried out beforethe operation. The procedure of anaesthesia to be given wasexplained to the patients and written informed consent wastaken accordingly.Results: The mean age (in years) of the midazolam group was35.54 ± 8.5 and it was 34.06 ± 10.2 in the thiopentone group.We found a statistically significant difference of weight,spontaneous closure of eye, Loss of lid reflex between boththe groups. Patient Good acceptance was good in 16 (66.67%)participants in midazolam and 8 (33.33%) participants in thethiopentone group.Conclusion: We conclude that midazolam is a satisfactorysubstitute to thiopentone.