RESUMO
The aim of the present work was to evaluate serum level of CA125 as a predictor of the outcome of early pregnancies complicated by vaginal bleeding. 88 patients suffering from vaginal bleeding during the first trimester of pregnancy were recruited from the out patient clinic of Suez Canal University Hospital. They were followed up till the 20[th] week of gestation. Serial Ultrasound examination and measurement of serum level of CA125 was done, using the IMMULITE Analyzer forming an immunometric Assay Analysis: Patients were classified into two groups according to the outcome of their pregnancy; Group [I] those who continued pregnancy up till 20 weeks and Group [II] those who eventually abort aborted before that. The results of the study showed that the mean serum level of CA125 was [76.59 and 137.45 U/ml] for both groups respectively and was found to be significantly higher in group [II]. The cut off level of 120 U/ml has a specificity of 90.91, a sensitivity of 79.55, a positive predictive value of 89.74 and a negative predictive value of 81.63. The results also showed that there was statistically significant negative correlation between CA125 serum level and duration of gestation showing a notable regular drop as pregnancy advances. There is a statistically significant difference in the mean level of serum CA125, being higher in cases that aborted compared to those who continued pregnancy. A cut off level of 120 U/ml could be considered as a predictive level for pregnancy outcome for cases with 1st trimester bleeding