RESUMO
Necroptosis, or programmed cell death, is a type of cell death with a controllable death signaling pathway and the morphological features similar to necrosis.It is mainly mediated by death receptors or pathogen pattern re-cognition receptors.Among them, tumor necrosis factor receptor 1 (TNFR1)-mediated necroptosis is the most well-studied one.Receptor-interacting protein kinase 1 (RIPK1) and receptor-interacting protein kinase 3 (RIPK3) are the 2 key kina-ses involved in the formation of complex I & II and necrosome in the process of necroptosis.Phosphoglycerate mutase 5 ( PGAM5) , a member of phosphoglycerate mutase gene family, lacks PGAM activity and possesses the phosphatase activi-ty.PGAM5 is anchored in the mitochondrial membrane and is also called mitochondrial phosphoglycerate mutase 5.It has been shown that PGAM5 involves in the formation of necrosome during necroptosis and it is able to accelerate the fission of mitochondria by dephosphorylation of dynamin-related protein 1 (DRP1), thus promoting cell necroptosis.