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Objective:To explore the causes of 12 cases with benign central airway stenosis, and to discuss the therapeutic effect of endotracheal intubation.Methods:Children with benign central airway stenosis in the People′s Hospital of Xinjiang Uygur Autonomous Region from January 2018 to December 2019 were selected.Their general cli-nical data, CT airway 3D reconstruction image data and the characteristics of tracheostenosis under bronchoscope were analyzed.A variety of combined bronchoscopic interventions (high-frequency cauterization, balloon dilatation, cryotherapy) were performed.Results:The clinical data of 12 children with benign central airway stenosis were collected, including 7 males and 5 females. The main causes of benign central airway stenosis in 12 cases were tracheal stenosis after intubation (9 cases, 75.00%), tracheoesophageal fistula (1 case, 8.33%), webbed stenosis (1 case, 8.33%) after tracheotomy, and right main bronchus stenosis after foreign body entrance (1 case, 8.33%). After treatment for 4 weeks [(4.48±0.61) mm], 6 months[(5.49±0.52) mm] and 1 year[(6.13±0.26) mm ], the diameter of stenotic airways increased significantly compared with that before treatment[(1.98±0.48) mm], and the diameter of stenotic airways increased gradually with the time of follow-up ( t=12.871, 9.302, 6.737, all P<0.001); the modified British Medical Research Council scale(MMRC)score decreased significantly after treatment [4 weeks(1.17±0.94)scores, 6 months ( 0.58±0.67) scores, 1 year (0.25±0.45) scores] compared with that before treatment[(3.17±0.58) scores], and the MMRC score decreased gradually with the increase of follow-up time ( t=11.489, 3.924, 2.345, all P<0.05) . Conclusions:The most common causes of benign central airway stenosis in children are tra-cheal intubation or tracheotomy.The combination of a variety of endotracheal endoscopic interventions (high-frequency cauterization, balloon dilatation, cryotherapy) is effective in the treatment of this disease.
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Objective To investigate the relationship between homocysteine and essential hypertension in Kazakh adolescent from pasturing area of Xinjiang.Methods We recruited 84 patients with essential hypertension(case group) and 100 controls without hypertension (control group).Fasting blood were obtained from all subjects.Then we measured the homocysteine levels in all subjects.We analyzed the relationship between homocysteine and essential hypertension in Kazakh adolescent from pasturing area of Xinjiang finally.Results After adjusting of sex,age,body mass index,and family history,compared with the control group,the homocysteine levels in case group increased and had significant difference(P ＜ 0.001).The results of Logistic regression analysis suggested that after adjusting of sex,age,body mass index,and family history,the OR value of essential hypertention increased with homocysteine(OR =10.23,P ＜ 0.001).Positive correlation existed between plasma homocysteine levels and systolic blood pressure(r =0.722,P ＜ 0.001),and diastolic blood pressure (r =0.534,P ＜0.001) after adjusted of sex,age,body mass index,and family history by using partial correlation analysis.Conclusion In Kazakh adolescent from pastoral areas of Xinjiang,homocysteine was associated with essential hypertension and blood pressure level.The higher homocysteine level was an independent risk factor for essential hypertension in Kazakh adolescent from pasturing area of Xinjiang.