RESUMO
Aims: Narrowing of the upper airway during sleep causes snoring, hypoventilation and decreased oxygenation of the brain with recurrent arousal from sleep and a cascade of excessive daytime sleepiness, poor concentration in class and undesirable academic performance. This study determined the prevalence of day time sleepiness among students in secondary schools in Ibadan and establishes its association with body mass index, tonsil size, Mallampati score, and academic performance. Study Design: A prospective, cross sectional community based study. Place and Duration of Study: Ibadan town, Nigeria between August 2013 and July 2014. Methodology: This school-based cross-sectional study recruited the students by systematic random sampling technique. The participants answered an interviewer assisted structured questionnaire and had clinical examination for structural abnormalities of the oropharynx, Mallampati score, tonsillar grade and the BMI. The academic performances were determined using the overall mean average score of all the subjects offered during the first and second term of the academic session. The test of association between daytime sleepiness and other variables were determined. Statistical analysis of the data was done with Statistical Package for Social Sciences (SPSS) version 16. Results: There were 493 participants consisting 262 (53.1%) males and 231(46.9%) females (M: F ratio of 1.1:1), the mean age was 12.6 years + 2.6 (range = 9-17 years) and the mean BMI was 22.60 kg/m2±3.0 (range= 15.7 - 35.2 kg/m2). Daytime sleepiness was encountered in 56 (11.4%) of the students, this was association with high Mallampati score (p < 0.001), high BMI (p < 0.001), but had no association with academic performance (p = 0.54), tonsillar enlargement (p = 0.35), gender (0.82) and overnight sleeping duration (p = 0.21). Conclusion: The prevalence of daytime sleepiness among the secondary school students was 11.4%, and had no associated with academic performance. High BMI and Mallampati score were the significant risk factors identified.
RESUMO
Aims: To evaluate salivary and serum IgG levels in patients with head and neck squamous cell carcinoma (HNSCC) and healthy control subjects and to assess the effect of treatment on IgG levels. Study Design: A cross sectional study. Place and Duration of Study: Department of Oral Pathology and Department of Radiotherapy, University College Hospital, Ibadan, Nigeria between January 2010 and December 2010. Methodology: Seventy eight subjects comprising 30 patients with untreated HNSCC, 18 patients with HNSCC receiving treatment and 30 healthy, age and gender-matched individuals were included. Serum and salivary samples from the participants were analysed for total IgG using ELISA technique. Results: The mean serum IgG in untreated and treated HNSCC patients was significantly lower compared with healthy controls (P=.001), while mean salivary IgG was significantly elevated (P=.001) in untreated HNSCC patients compared with treated and healthy controls. There was no significant correlation between serum and salivary IgG levels. Conclusion: In patients with head and neck squamous cell carcinoma, serum IgG was reduced while salivary IgG was elevated compared with healthy controls. Our finding suggests differential roles of immunoglobulin G in serum and saliva of patients with head and neck squamous cell carcinoma. Hence, salivary IgG may be a useful biomarker in patients with head and neck squamous cell carcinoma, while serum IgG levels may be useful in monitoring treatment in these individuals.