Ayurvedic Management of Primary Infertility Associated with PCOS - A Case Report

Poly cystic ovarian syndrome is a condition characterised by a wide range of signs and symptoms including menstrual irregularities, obesity, acne, hirsutism and is causing adverse effects on metabolic and endocrinal system. Exact etiology and pathophysiology is still unclear but it’s having a strong familial predisposition. This is a case report on an anovulatory infertility caused by PCOS. A 27-year-old female patient presented to the Streeroga OPD at ITRA On December 29, 2020, complaining of infertility, irregular and delayed menstruation, and weight gain over the past three years. She has been taking allopathic medicine for the same for the last two years. During her initial opd visit, she received a thorough medical history as well as all relevant clinical, physical, and laboratory tests. Bulky ovaries with polycystic morphology were discovered on sonography. Anovulatory factor infertility owing to PCOS was determined based on clinical symptoms and sonography. Pathadi choorna and Arogyavardhini rasa were chosen as medications and Samana oushadha was chosen as the line of management. The patient was counselled on lifestyle changes, the need of exercise, and correction of food habits. Patient was under medication for a period of 5 months. Patient got conceived after that and on 8th February 2022 she gave birth to a healthy male baby per vaginally with a baby weight of 3.2 kg.

Pregnancy-Induced Hypertension - Ayurvedic Understanding

Pregnancy-induced hypertensive disorders are included among the most common medical complications of pregnancy with an incidence of 5–10%. Hypertension that develops as a direct result of gravid state is referred to as ‘pregnancy-induced hypertension’. The timely management of pregnancy complicated with hypertensive disorders is significant, otherwise it can lead to adverse fetal, neonatal and maternal outcomes. The basic pathology in pre-eclampsia, one of the types of hypertensive disorders is endothelial dysfunction and intense vasospasm due to abnormal placentation compromising blood flow to the foetoplacental unit. There is no direct reference of pregnancy-induced hypertension in Ayurveda classics, but the manifested symptoms can be explained within the purview of Ayurveda. Abnormality in placentation can be considered as impairment in the normal functioning of Vata dosha and when the pathology progresses further; Kapha, Pitta also play their own roles. In a woman with or without a previous history of pre-eclampsia, intervention should begin from pre-conceptional period. Planned pregnancy after pre-conceptional care followed by Garbhini paricharya along with the use of Garbhasthapaka dravya, Rasayana dravya, Masanumasika Garbhasravahara dravya can play significant roles in the prevention as well as management of pregnancy-induced hypertension thus improving the maternal and foetal outcomes.

Pharmacognostical, Phytochemical and HPTLC Profile of Vayasthapana Gana Choorna and Vayasthapana Ghrita- A Poly-Herbal Compound

Menopausal syndrome is a grouping of signs and symptoms associated with menopause. In Ayurveda, menopause is referred to as 'Rajonivrutti' (and menopausal syndrome as Rajonivruttianubandhaja vyadhies). Menopause's long-term risks include osteoporosis, cardiac problems, and Alzheimer's disease. Aims and objective: To study the Pharmacognostic, Phytochemical and HPTLC of Vayasthapana Gana Choorna and Vayasthapana Ghrita. Material and methods: Pharmacognostic, phytochemical and HPTLC of Vayasthapana Gana Choorna and Vayasthapana Ghrita have been carried out as per standard protocol. Result: Vayasthapana Gana Choorna showed the presence of mesocarp, asicular crystals, stone cells, scleroids, brown content, starch grains, colencyma cells, rhomboidal crystals, pitted vessels, parenchyma cells, simple trichome. Phytochemical parameters showed refractive index 1.3660, specific gravity 0.913, acid value 1.285, iodine value 212.1085 and in HPTLC, Methanol extract of Vayasthapana Ghrita at 254nm showed 6 spots and at 366nm 2 spots whereas in methanol extract of Vayasthapana Gana Choorna at 254nm 5 spots and in 366nm 4 spots were present. Conclusion: The applied pharmacognostic and HPTLC method has been shown to be selective, linear, precise and accurate. The method will be useful for quality control of the raw material and pharmaceutical preparations.

Ayurvedic Management Of Polycystic Ovarian Syndrome By Palasadi Basti And Pathadi Choorna: A Case Report

Polycystic Ovarian Syndrome is the most common disease in the female population among adolescence and reproductive age group mainly due to the adoption of westernized culture. Polycystic Ovarian Syndrome (PCOS) is a physiological disorder that causes many negative effects involving a variety of systems in the body, such as the endocrine, metabolic, psychological, and reproductive systems. The complex symptomatology of PCOS makes very difficult to treat as a whole. In Ayurveda also no disease can be compared directly with PCOS. Some of clinical symptoms of PCOS may simulate Granthibhoota Artava dushti and if not treated early lead to the full manifestations and complications of PCOS. A 26 year old female came to OPD of Streeroga of IPGT & RA, having the complaints of irregular cycle, weight gain and failure to conceive since 2 years of active married life with a previous history of abortion. Sonography revealed bulky ovaries with multiple small follicles. Based on clinical findings along with sonological evidences Polycystic Ovarian Syndrome was diagnosed and a treatment protocol was selected for managing the PCOS and finally to achieve conception. Palasadi basti was selected followed by Pathadi choorna orally with warm water as internal medicine. The treatment was done for 3 months and during follow up the cycles became regular and finally the patient got conceived within 2 months.

Effect of Aloe barbadensis Mill. formulation on Letrozole induced polycystic ovarian syndrome rat model.

This is a preliminary study that explores the efficacy of Aloe vera gel formulation as a possible therapeutic agent in the prevention and management of polycystic ovary syndrome (PCOS). PCOS is recognized as the most common endocrinopathy of women. Increased androgen synthesis, disrupted folliculogenesis, and insulin resistance lie at the patho-physiological core of PCOS. Current therapy for such a syndrome is use of insulin sensitizers. Large randomized clinical trials of metformin as the insulin-sensitizing drug, however, suggested that it produces many side effects after prolonged usage. For this reason, an alternate therapy would be to use herbs with hypoglycemic potential. Aloe barbadensis Mill. (Liliaceae) popularly known as Aloe vera is a well-known plant with such properties. The present study evaluated the efficacy of Aloe vera gel formulation in a PCOS rat model. Five month old Charles Foster female rats were orally fed with letrozole, a non-steroidal aromatase inhibitor, to induce PCOS. The rats were then treated orally with the Aloe vera gel formulation (1 ml dose daily for 45 days). This restored their estrus cyclicity, glucose sensitivity, and steroidogenic activity. Co-treatment of the inductive agent (letrozole) with the Aloe vera gel prevented the development of the PCO phenotype. Aloe vera gel formulation exerts a protective effect in against the PCOS phenotype by restoring the ovarian steroid status, and altering key steroidogenic activity. This can be attributed to phyto-components present in the extract.

Effect of low level exposure of lead and cadmium on hepatic estradiol metabolism in female rats.

Toxic effect of metal cations on female reproduction and gonadal functions was studied. Adult synchronized female rats were treated intraperitoneally with lead acetate and cadmium acetate separately and in combination (0.025, 0.05 and 0.1 mg/kg body wt) for 15 days. The metabolizing enzymes (17beta-hydroxy steroid oxidoreductase and UDP glucoronyl transferase) activities decreased with increasing dose showing significant change compared to control. Also, significant decrease in cytochrome P450 (CYP450) content was found after the treatment. Displacement of zinc bound to metallothionein was more in cadmium treated rats compared to other groups. In all these parameters, treatment in combination of lead and cadmium showed intermediate results indicating some kind of competition between the two metals. But the histological studies showed that combined treatment caused more cytotoxic effect than cadmium and lead alone. These results indicated that metal cations tested did have a direct inhibitory effect on metabolizing enzyme activities.