RESUMO
OBJECTIVE: To investigate the chemical constituents in the fruits of Cerbera manghas Linn. METHODS: Silica gel column, HPTLC, and Sephadex LH-20 chromatography were applied to isolate the chemical constituents. The structures of the isolated compounds were elucidated by spectroscopic techniques and physicochemical properties. RESULTS: Fifteen compounds were isolated and identified including eleven phenolic acids, i.e., benzoic acid(1), vanillic acid(2), vanillin(3), p-hydroxybenzaldehyde(4), isophthalaldehydic acid(5), β-hydroxygpropiovanillone(6), ficusol(7), evofolin B(8), 3, 4'-dihydroxypropiophenone(9), p-hydroxybenzoic acid(10), protocatechuic acid(11), one monoterpene, i.e., cerbinal(12), two cardiac glycosides, i.e., 17-β-neriifolin(13) and cerberin(14), and one triterpenoid, i.e., ursolic acid(15). CONCLUSION: All the compounds except compound 13 and 14 are obtained from the fruits for the first time. Compound 5 is a new natural product, and compounds 1, 3, 6-9, and 15 are obtained from genus Cerbera for the first time.