Comparison of metabolic parameters in children and adolescents with and without insulin resistance / Comparação de parâmetros metabólicos em crianças e adolescentes com e sem resistência à insulina

ABSTRACT The aim of the study was to compare the behavior of metabolic parameters, blood pressure, and obesity indicators in children and adolescents with and without insulin resistance. Sixty-one overweight children (6 to 18 years) underwent anthropometric measurements of body mass (BM), height and waist circumference (WC), blood pressure (BP), bioimpedance (relative (%F) and absolute fat (BF)), and blood collection for determination of glucose, insulin, and lipid profile (TG, CT, HDL-C, LDL-C). The BMI z-score was used to classify nutritional status and the HOMA-IR index (> 2.5) for insulin resistance. Participants were divided into two groups, insulin resistant (IR, n= 27) and non-insulin resistant (NIR, n= 33). Regardless of age, children and adolescents with excess weight and IR presented higher BM, WC, BMI, %F and BF (kg), TG, and plasma insulin than their NIR counterparts, who in turn presented higher LDL-C. The groups did not differ in nutritional status (BMI z-score); however, in the comparison between the undesired proportions of the metabolic components, only three presented alterations with significant differences between the groups (TC, LDL-C, and TG). It is concluded that IR influences the development of dyslipidemias in this age group, especially TG.

RESUMO O objetivo do estudo foi comparar o comportamento de parâmetros metabólicos, pressão arterial e indicadores de obesidade em crianças e adolescentes com e sem resistência à insulina. Participaram do estudo 60 crianças e adolescentes com excesso de peso (6 a 18 anos)que foram submetidos amedidas antropométricas de massa corporal (MC), estatura ecircunferência da cintura (CC), pressão arterial (PA), bioimpedância[gordura relativa (%G) e absoluta (GC)] e coleta sanguínea para determinação das concentrações de glicose, insulina e perfil lipídico (TG, CT, HDL-C, LDL-C). O IMC z-scorefoi empregado para classificação do estado nutricional e o índice HOMA-RI (>2,5) para resistência à insulina.Os participantes foram divididos em dois grupos, resistentes (RI, n=27) e não resistentes à insulina (NRI, n=33).Independente da idade, crianças e adolescentescom excesso de peso e RI, apresentaram maior MC, CC, IMC, %G e GC (kg), TG e insulina plasmática do que contraparesNRI, que por sua vez, apresentaram valores mais elevados de LDL-C. Os grupos não diferiram para oestado nutricional(IMC z-score)porém, na comparação entre as proporções indesejadas dos componentes metabólicos, apenas três apresentaram alterações com diferenças significativas entre os grupos (CT, LDL-C e TG). Conclui-se que a RI apresenta-se com influência para o desenvolvimento de dislipidemias nessa faixa etária em especial o TG.

Effect of Treatment With Msg on Growth, Satiety and Epididymal Adiposity in Neonatal Rats.

This study aims to evaluate the relationship between morphological and metabolic parameters in obese rats induced by MSG, using exercise to determine the glycemic response between animals. Were constituted by 10 adult female Wistar rats, 4-month-old boy with obesity induced by MSG. They measured levels of intake of food and water for a week, and after, there was a swimming test lasting 60 minutes. The results are expressed as mean and standard deviation. It was used the Student t-test for independent samples, a significant difference when considering p<0.05. Occur significant difference between the length of the small intestine, where the obese group has the gut lower 14% (13 cm) compared to the normal group (p<0.05). Regarding the body weight, the average weight of the MSG group was significantly lower (82%; 37g, p<0.05) compared to the Control group. The opposite occurred with visceral adiposity, performing significantly higher in MSG group (54%; 8g, p<0.05) from the average of the Control group. We conclude that the consumption of MSG may lead to obesity by increasing body fat and visceral also morphological differences in the size of the gut and body weight.