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1.
Cir. & cir ; 76(3): 225-233, mayo-jun. 2008. graf, tab
Artigo em Espanhol | LILACS | ID: lil-567104

RESUMO

BACKGROUND: Hyperlipidemias are the main risk factors for atherosclerosis and cardiovascular disease. Nevertheless, the protein fractions of these lipids such as apolipoprotein B (Apo-B) can lead to arterial obstruction. In this study we investigated levels of apolipoproteins AI and B in patients with chronic occlusive peripheral arterial disease (PAD) of the lower extremities and their association with either patency or stenosis of synthetic grafts. METHODS: This cohort study included 24 patients with chronic occlusive PAD who underwent infrainguinal revascularization with polytetrafluoroethylene (PTFE) synthetic graft. Patients were divided into two groups according to whether or not they were exposed to Apo-B, thus integrating two cohorts: the unexposed group (group 1, normal levels of Apo-B) and the exposed group (group 2, high levels of Apo-B). Variables investigated at 3, 6 and 12 months included arm/ankle index (AAI) and its association with levels of Apo-AI and Apo-B, and levels of cholesterol, triglycerides, and fibrinogen. RESULTS: The study was comprised of 67% men and 33% women. Average age was 65.2 +/- 8.4 years. There was a correlation between AAI and high levels of Apo-B (p <0.001). Apo-AI levels were not significantly different between groups. Fibrinogen remained elevated in both groups with no statistical difference. Triglycerides demonstrated a significant difference between groups in basal measurements (p <0.05). Cholesterol remained normal in both groups without statistical difference. CONCLUSIONS: This study demonstrates that patients exposed to high levels of Apo-B had synthetic graft failure (obstruction), as demonstrated by AAI <1.


Assuntos
Humanos , Masculino , Feminino , Idoso , Apolipoproteína A-I/sangue , Apolipoproteínas B/sangue , Doenças Vasculares Periféricas/cirurgia , Prótese Vascular/efeitos adversos , Estudos de Coortes , Complicações Pós-Operatórias/sangue , Complicações Pós-Operatórias/etiologia , Constrição Patológica/sangue , Constrição Patológica/etiologia , Biomarcadores/sangue , Procedimentos Cirúrgicos Vasculares/efeitos adversos
2.
Arch. Inst. Cardiol. Méx ; 69(4): 344-9, jul.-ago. 1999. tab, graf, ilus
Artigo em Espanhol | LILACS | ID: lil-258844

RESUMO

Se presentan 3 casos de mujeres portadoras de estenosis mitral pura con área valvular < 1 cm², que por falta de respuesta a tratamiento médico, se sometieron a valvuloplastía mitral percutánea (VMP) con técnica de Inoue antes de la semana 30 del embarazo. Desde su ingreso recibieron heparina de bajo peso molecular (HBPM; Enoxaparina) como profiláctico de formación de trombos intracavitarios y enfermedad embolígena sistémica secundaria, se realizó ecocardiogramas transtorácico y transesofágico (ETT y ETE) para demostrar efecividad del fármaco en evitar formación de trombos, sin causar efectos colaterales en la madre ni teratogénicos en el producto. La dosis utilizada fue de 40 mg. Subcutáneo cada 24 hs. durante 16 semanas en las tres pacientes, se repitió el ETT y ETE durante la VMP y se demostró ausencia de trombos intracavitarios. Ninguna paciente presentó alteraciones en la biometría hemática, ni en los tiempos de coagulación. Se obtuvieron productos sin malformaciones. En conclusión, aunque la serie de pacientes es pequeña, se demostró que la HBPM puede utilizarse como alternativa del uso de anticoagulante oral así como de la heparina convencional, como profiláctico durante el primer trimestre del embarazo sin provocar efectos secundarios indeseables


Assuntos
Humanos , Feminino , Recém-Nascido , Adulto , Anticoagulantes/uso terapêutico , Coagulação Sanguínea , Estenose da Valva Mitral/tratamento farmacológico , Heparina de Baixo Peso Molecular/uso terapêutico , Contagem de Células Sanguíneas , Ecocardiografia Transesofagiana , Eletrocardiografia , Estenose da Valva Mitral/complicações , Estenose da Valva Mitral , Gravidez , Trombose/prevenção & controle
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