Nosocomial Infection with Pseudomonas aeruginosa and Approach of Drug-resistance:A Clinical Overview / 中华医院感染学杂志

OBJECTIVE To investigate nosocomial infection and drug-resistance of Pseudomonas aeruginosa(PAE) in our hospital to provide the evidence for clinical monitoring and control of nosocomial infection.METHODS The microbiological system MicroScan WalkAway-40 was used to identify PAE and the drug-resistance in vitro was determined by K-B methods.RESULTS Among 325 strains of PAE in two years,imipenem-resistant P.aeruginosa(IRPA) accounted for 14.8%.The highest isolating rates occurred in the intensive care unit(ICU),accounted for 20.9%.The following was senile disease department,accounted for 19.4%.The respiratory department rated the third,accounted for 16.9%.The resistance of IRPA to 11 kinds of common antibiotics was significantly higher than imipenem-sensitive P.aeruginosa(ISPA).Except the drug-resistance of IRPA to ceftazidime,cefepime and aztreonam was below 50.0%,that to the other eight antibiotics was all over 50.0%.CONCLUSIONS The drug-resistance of PAE is very serious in our hosptial.We should perform rigorous monitoring and prevent the outbreak of nosocomial infection with PAE.

Chronic Obstructive Pulmonary Disease Patients with Gram-negative Bacteria Nosocomial Pneumonia / 中华医院感染学杂志

OBJECTIVE To study the organism and drug resistance in chronic obstructive pulmonary disease(COPD) patients with Gram-negative bacteria(GNB) nosocomial pneumonia,in order to provide the index to clinician. METHODS The bacteria were tested by Micro WalkAway-40 which made in the USA,the susceptibility test was carried by disk diffusion test. RESULTS The rates of Klebsiella pneumoniae and Pseudomonas aeruginosa among all bacteria were higher,which were 26.8% and 26.2%,respectively;the organisms were almost drug resistant,which were more sensitive to imipenem,amikacin and ceftazidime,and more resistant to other drugs. CONCLUSIONS The hospital should make precautions,diagnose in time,and use antibiotic reasonably.