Detection of artificial musk in Xihuangwan by gas chromatography-mass spectrometery / 中国医学科学院学报

<p><b>OBJECTIVE</b>To control the quality of Xihuangwan by improving the qualitative detection of artificial musk inside this pill.</p><p><b>METHOD</b>The qualitative detection of artificial musk was carried out by gas chromatography-mass spectrometery(GC-MS).</p><p><b>RESULT</b>The established GC-MS successfully detected artificial musk in Xihuangwan.</p><p><b>CONCLUSION</b>GC-MS is reliable,accurate,and practical in the identification of artificial must inside Xihuangwan.</p>

Determination of the content of residual solvents in muscone by head-space gas chromatography / 中国医学科学院学报

<p><b>OBJECTIVE</b>To explore the usefulness of a head-space gas chromatography in the determination of residual solvents including methanol,ethanol,ethyl ether,and petroleum ether in muscone in artificial musk.</p><p><b>METHODS</b>The head-space gas chromatography was performed on HP-5(30 m×0.53 mm,5 Μm)capillary column with a hydrogen flame ionization detector. The carrier gas was nitrogen and the solvent was dimethyl sulfoxide. The injector temperature and the detector temperature were controlled at 180 ℃ and 250 ℃,respectively. The containers of head-space injector were preheated at 80 ℃ for 15 minutes. The column temperature was programmed raised,which achieved baseline separation of the components.</p><p><b>RESULTS</b>The results showed a good linear relationship for methanol,ethanol,ethyl ether,and petroleum ether(60-90 ℃)in the range of each consistency; and the limit of detection was 0.8,1.0,0.1,and 0.3 Μg/ml,respectively. The precision and average recoveries were satisfactory.</p><p><b>CONCLUSION</b>The head-space gas chromatography is simple,rapid,and precise technique for measuring residual solvents in muscone.</p>