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1.
China Journal of Chinese Materia Medica ; (24): 2089-2094, 2007.
Artigo em Chinês | WPRIM | ID: wpr-307506

RESUMO

Lignans are widely existed in natural world with a variety of structures and bioactivities, including anti-tumor, antiinflammatory, anti-viral and hepatoprotective properties. Along with the development of new techniques in phytochemistry and application of advanced drug screening methods, a variety of lignans have been identified and their bioactivities revealed. In this review, we summarized the activities of six different types of lignans, including arylnaphthalene, dibenzylbutyrolactone, tetrahydrofuran, dibenzylbutane, dibenzocyclooctadiene and neolignan, in order to provide an updated overview of this research field.


Assuntos
Animais , Humanos , Anti-Inflamatórios , Química , Farmacologia , Antineoplásicos Fitogênicos , Química , Farmacologia , Antivirais , Química , Farmacologia , Ciclo-Octanos , Química , Farmacologia , Furanos , Química , Farmacologia , Lignanas , Química , Farmacologia , Estrutura Molecular , Plantas Medicinais , Química
2.
China Journal of Chinese Materia Medica ; (24): 827-830, 2005.
Artigo em Chinês | WPRIM | ID: wpr-358078

RESUMO

<p><b>OBJECTIVE</b>To study the chemical constituents in roots of P. fallax and their anti-oxidation activities in vitro.</p><p><b>METHOD</b>Column chromatographic techniques were employed for isolation and purification of chemical constituents of the plant. The structures were elucidated on the basis of the spectral evidence and the physical and chemical character. The isolated compounds were screened with four anti-oxidation models in vitro.</p><p><b>RESULT</b>Seven xanthones, 1,7-dihydroxy-2,3-methylenedioxyxanthone (1), 1-methoxy-2,3-methylenedioxyxanthone (2), 3-hydroxy-1,2-dimethoxyxanthone (3), 1,6,7-trihydroxy-2,3-dimethoxyxanthone (4), 7-hydroxy-1-methoxy-2,3-methylenedioxyxanthone (5), 1,3-dihydroxy-2-methoxyxanthone (6) and 1,3,7-trihydroxy-2-methoxyxanthone (7), were isolated from the roots of P. fallax. And compounds 1 - 7 showed different anti-oxidation activities in the different pharmacological models.</p><p><b>CONCLUSION</b>Compounds 2, 3, 5 and 7 were isolated from this plant for the first time. Xanthones from this plant showed anti-oxidation activities. The pharmacological activities of the pure compounds from this plant were also reported for the first time.</p>


Assuntos
Animais , Ratos , Antioxidantes , Farmacologia , Peroxidação de Lipídeos , Macrófagos , Fisiologia , Mitocôndrias Hepáticas , Metabolismo , Oxirredução , Raízes de Plantas , Química , Plantas Medicinais , Química , Polygala , Química , Explosão Respiratória , Xantonas , Farmacologia
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