1.
Acta Pharmaceutica Sinica
;
(12): 979-984, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-232656
RESUMO
The importance of insulin-like growth factor 1 receptor (IGF-1R) signaling in malignant behaviour of tumour cells is well established. Inhibiting the activity of IGF-1R may result in striking apoptosis in malignant cells growing. IGF-1R antibodies which are currently in phase I and II clinical trials and several IGF-IR TKIs have preclinically been characterized. This review describes recent developments of small molecule tyrosine kinase inhibitors.