Clinical features of non-allergic rhinitis and the therapeutic efficacy of combination of intranasal steroid and H1-antihistamine / 中华耳鼻咽喉头颈外科杂志

<p><b>OBJECTIVE</b>To investigate the basic clinical features of non-allergic rhinitis (NAR) in age, sex, incentives, and the effect of treatment with combined intranasal steroids and antihistamines.</p><p><b>METHODS</b>One hundred consecutive NAR patients were included in this study and the age, gender, predisposing factors and clinical symptoms were analyzed. Combined intranasal steroids and antihistamines used for 8 weeks, the symptoms were recorded before and after treatment with visual analogue scale(VAS) score as the assessment of treatment effects. SPSS 17.0 software was used to analyze the data.</p><p><b>RESULTS</b>Ninety-three NAR patients were adults, and the sex ratio was 1:1.2 (male:female), and the peak age incidence was between 30 - 39 years old. The main nasal symptoms were sneezing (96 cases), rhinorrhea (88 cases), nasal blockage (72 cases) and nasal itching (69 cases). The symptoms of eye and respiratory tract were always accompanied as eye itching (49 cases), tears (32 cases), congestion (22 cases), swelling (13 cases), cough (21 cases), suffocation (19 cases), chest compression (13 cases), wheezing (10 cases); Seventy-nine (79.0%) patients could indicate at least one kind of incentives, the temperature change (54 cases), dust (28 cases), irritating odor (21 cases) was the main incentive of NAR. Forty-seven patients completed the combined treatment of intranasal steroids and antihistamines, 38 (80.9%) patients were satisfied with the result with all symptoms relieved except wheezing (P < 0.05), but 36 patients had the NAR returned when they were exposed with the predisposing factors in the coming year; the remaining 9 (19.1%) patients failed the treatment.</p><p><b>CONCLUSIONS</b>The clinical features of NAR were as follows: adult constituted the main patient population, women were slightly more than man but with no difference between genders; sneezing and nasal discharge were the main clinical symptoms, always more than 1 incentives. The combination of intranasal steroids and antihistamines could control the most of clinical symptoms.</p>

The expression of DcR3 in gastrointestinal tumors / 肿瘤

Objective: To study the expression of decoy receptor 3 (DcR3) in gastrointestinal tumors and elucidate the relationship between DcR3 and gastrointestinal tumors. Methods: The human colon carcinoma cells (SW480), gastric cancer cells (SGC7901), hepatoma carcinoma cell (HepG2) and human fibroblasts (3T3) were cultured in vitro. The expression level of DcR3 mRNA was determined by RT-PCR. The level of DcR3 protein expression was detected by Western blotting. Results: The mRNA and protein expression levels of DcR3 were higher in the SW480 cells than those in SGC7901, HepG2, and 3T3 cells. The difference was significant (P <0.05). Conclusion: Over-expression of DcR3 gene in the colon carcinoma cells may be related with the initiation and development of colon cancer.