Nuclear medical molecular imaging of tumor angiogenesis: current status and future prospects / 中华医学杂志(英文版)

<p><b>OBJECTIVE</b>To review the current status and progress on nuclear medical molecular imaging of angiogenesis.</p><p><b>DATA SOURCES</b>A literature search was performed in Medline and PubMed published in English up to May 31, 2012. The search terms were molecular imaging, nuclear medicine and angiogenesis.</p><p><b>STUDY SELECTION</b>Articles studying molecular imaging of angiogenesis using radionuclide were selected and reviewed.</p><p><b>RESULTS</b>Molecular imaging has been used for studying angiogenesis by targeting integrin αVβ3, VEGF/VEGFR, and matrix metalloproteinases (MMPs) with radionuclide-labeled tracers. The technology has been shown to be able to assess the angiogenesis status and/or predict the efficacy of anti-angiogenic therapy. Future directions of the research on the molecular imaging of angiogenesis include development of new tracers with better tumor targeting efficacy, desirable pharmacokinetics, and easy translation to clinical applications.</p><p><b>CONCLUSION</b>Advances in molecular imaging of angiogenesis using radioculcide will make the technology a valuable tool for personalized anti-angiogenesis treatment.</p>

The prognostic value of metabolic tumor volume in FDG PET/CT evaluation of post-operative survival in patients with esophageal squamous cell cancer / 中华核医学杂志

ObjectiveTo evaluate the prognostic value of MTV on 18F-FDG PET/CT in patients with esophageal cancer.MethodsForty-nine patients with esophageal cancer underwent 18 F-FDG PET/CT scan before surgery.The median follow-up time for the patients was 29 months (range,8- 57 months).The prognostic significance of MTV,age,sex,histologic grade,SUVmax of the primary tumor,tumor size measured on PET/CT,T stage,N stage,M stage,American Joint Committee on Cancer (AJCC) stage,number and location of lymph nodes metastases were assessed by Kaplan-Meier analysis and multivariate Cox model.ResultsIn the univariate analysis,AJCC stage (x2 =16.206,hazard ratio (HR) =1.177,P ＜0.001),N stage (x2 =9.536,HR =10.833,P =0.002),T stage (x2 =5.810,HR=2.397,P=0.016),number of lymph nodes metastases (x2 =11.423,HR =1.567,P =0.001 ),and MTV (x2 =3.872,HR =2.433,P =0.049 ) were significant predictors of survival.Multivariate analysis showed that MTV and AJCC stage were independent predictors of survival (x2 =4.525,HR1.170,P =0.033 ;X2=4.875,HR =3.071,P =0.027).Kaplan-Meier survival curves revealed longer survival time of low-MTV group as compared to high-MTV group ( Log-rank,x2 =4.186,P =0.041 ).ConclusionMTV on 18 F-FDG PET/CT may be an independent prognostic factor in patients with esophageal cancer.

Clinical value of positron emission tomography-CT for the diagnosis of postoperative recurrence and metastasis in the patients with esophageal cancer / 中华胃肠外科杂志

<p><b>OBJECTIVE</b>To evaluate the clinical value of the whole-body (18)F-fluoro-deoxy-D-glucose positron emission tomography with computerized tomography (PET-CT) for recurrence and distant metastasis after curative resection of the esophagus cancer.</p><p><b>METHODS</b>From June 2003 to June 2004, thirty-one patients with clinical or radiologic suspicion of recurrent disease underwent conventional diagnostic work-up, including a spiral CT scan, and a dedicated whole-body PET-CT. All cases were examined by pathology or followed-up for 6 months.</p><p><b>RESULTS</b>Among the 31 cases, recurrences were found in 23 patients, and 43 recurrent lesions were detected, including 14 perianastomotic lesions and 43 regional and distant lesions. For the diagnosis of recurrence, the accuracy, sensitivity and specificity of PET-CT were 97.7%, 100%, and 85.7%, while those of conventional CT were 77.3%, 61.7%, and 78.6% respectively. The sensitivity of PET-CT was significantly higher than that of conventional CT (100% vs 61.7%; chi (2)=4.161, P=0.041).</p><p><b>CONCLUSIONS</b>The sensitivity of PET-CT is higher than that of conventional CT. PET-CT will play an important role in the diagnosis of postoperative recurrence and metastasis of esophageal cancer.</p>

Value of 18F-FDG PET in clinical staging of non-small-cell lung cancer / 中华肿瘤杂志

<p><b>OBJECTIVE</b>To evaluate the feasibility of 18F-deoxyglucose positron emission tomography (18F-FDG PET) in the staging of non-small-cell lung cancer (NSCLC).</p><p><b>METHODS</b>105 patients with NSCLC had been examined by 18F-FDG PET and staged by PET before radiotherapy. The results of 18F-FDG PET examination were compared with those of CT.</p><p><b>RESULTS</b>The staging was changed in 38 patients because of 18F-FDG PET findings with PET upstaged in 31 patients and downstaged in 7 patients. Because of distant metastasis detected by PET, 21 patients received palliative treatment. Six of the 7 downstaged patients underwent radical surgery, among which the PET findings were concordant with the operative findings in 5 patients. Distant metastasis detected by PET increased with elevation of pre-PET stage: at stage I 10.0% (2/20), stage II 14.3% (3/21) and stage III 25.0% (16/64), respectively.</p><p><b>CONCLUSION</b>18F-FDG PET, by changing clinical staging in 36.2% (38/105) NSCLC patients has impact on treatment strategy in NSCLC patients.</p>