Clinical observation on effect of tiaozhi jiangtang tablet on patients with diabetes of blood stasis syndrome: a report of 30 cases / 中国中西医结合杂志

<p><b>OBJECTIVE</b>To observe the clinical efficacy of Tiaozhi Jiangtang Tablet (TZJT) on patients suffering from diabetes mellitus with blood stasis syndrome.</p><p><b>METHODS</b>Sixty patients were randomly assigned into 2 groups, the TZJT group (n = 30) treated with TZJT tablet and asprin, the control group (n = 30) treated with asprin alone.</p><p><b>RESULTS</b>The improvement of symptoms was more significant in the TZJT group than that in the control group (P < 0.05). Levels of serum endothelin (ET), nitric oxide (NO) content and blood viscosity were decreased in both groups after treatment, and the effect of TZJT plus asprin was superior to that of asprin alone.</p><p><b>CONCLUSION</b>TZJT combined with asprin is effective in improving the serum content of ET and NO and reducing blood viscosity.</p>

Intervention effects of tiaozhi jiangtang tablet on insulin resistance in rats with diabetes mellitus type 2 / 中国中西医结合杂志

<p><b>OBJECTIVE</b>To observe the effect of Tiaozhi Jiangtang Tablet (TJT) on insulin resistance (IR) in rats with diebetes mellitus type 2.</p><p><b>METHODS</b>The model rats of diebetes mellitus were induced by intraperitoneal injection of streptozotocin (30mg/kg) and feeding with high lipid forage. The rats in the TJT group were treated with TJT and those in the metformin group treated with metformin as positive controls. The glucose infusion rate (GIR) was detected by glucose clamp technique after treatment for 8 weeks. At the same time, fasting blood glucose ( FBG), fasting insulin ( FINS), free fatty acids ( FFA), total cholesterol ( TC), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C) were measured respectively, and insulin sensitivity index (ISI) and HDL-C/TC calculated. The changes of insulin sensitivity and lipid metabolism were evaluated.</p><p><b>RESULTS</b>TC, TG, HDL-C/TC, FINS, and FFA significantly reduced in the TJT group as compared with those in the control group, while ISI and GIR significantly increased, the effects of TJT were similar to those of metformin.</p><p><b>CONCLUSION</b>TJT is effective in increasing insulin sensitivity and improving glucose and lipid metabolisms in rats with diebetes mellitus type 2.</p>

Preliminary exploration on effect of qilian decoction in intervention treatment of diabetes mellitus type 2 with insulin resistance and its influence on related inflammatory cytokines / 中国中西医结合杂志

<p><b>OBJECTIVE</b>To observe the synergistic effect of Qilian decoction (QLD) with corresponding hypoglycemic agents on insulin sensitivity in patients with diabetes mellitus type 2 and its influence on related inflammatory cytokines.</p><p><b>METHODS</b>Sixty-two patients with diabetes mellitus type 2 were selected and randomly divided into two groups, they were treated with hypoglycemic agent in routine, and QLD was given orally, one dose taken in twice a day. Parameters as fasting blood glucose, insulin, peptide C, tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), interleukin 6 (IL-6) were measured before and after treatment, and insulin sensitive index (ISI) was also calculated.</p><p><b>RESULTS</b>The level of fasting blood glucose lowered after treatment in both groups (P<0.01); levels of fasting insulin, peptide C, ISI, TNF-alpha, IL-6 and CRP significantly lowered after treatment (P<0.05 or P<0.01), and the effect was better than that in the control group (P<0.05 or P<0.01).</p><p><b>CONCLUSION</b>QLD could improve the insulin resistance and lower the levels of related inflammatory cytokines.</p>