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Journal of Medical Research ; (12)2006.
Artigo em Chinês | WPRIM | ID: wpr-565364

RESUMO

Objective To discuss the curative effects and side-effects of combining low-dose domestic interferon(sainuojin)with CHOPP-regimen in treating skin T-lymphoma.Method During the period June 1996 to June 2008,46 cases patient with skin T-lymphoma were treated by low-dose domestic interferon(sainuojin)and CHOPP-regimen,and all patient were received four cycle chemotherapy at least.And the usage was as follows:Sainuojin 3?106U/d,im,d1~21;CTX 600mg/m2,iv,d1;ADM 50mg/m2,iv,d1;VCR 1.4mg/m2,iv,d1;Predinisone 90 mg/d,PO,d1~5;PYM 8mg/d,im,d1,3,5,and every 3 weeks repeat.At the same time,the place of skin lesion was daubed with hydrochloric acid nitrogen mustard once everyday.Results CR 23 cases,PR 16 cases,NC 7 cases.The effective rate was 84.78%.The maximum time of survivorship was 11.6 years;the average survivorship time was 8.9?0.56 years;and the mostly side-effects were arrest of bone marrow and fever.Conclusion The curative effects of combining low-dose domestic interferon(sainuojin)with CHOPP-regimen in treating skin T-lymphoma were confirmed,and the side-effects were small.It is good for clinical popularization and application.

2.
Journal of Medical Research ; (12)2006.
Artigo em Chinês | WPRIM | ID: wpr-564672

RESUMO

Objective To study the relationships between serum IL-18 and IL-18BP and the development,metastasis,curative effect and prognosis of primary liver cancer.Methods There were total 49 cases patients,of which 28 cases primary hepaticcarcinoma(PHC)and 21 cases liver cirrhosis(LC),and 18 cases heathy people.Their serum levels of IL-18 and IL-18BP were determined by using an ELISA assay and comparation.Results The serum IL-18 in PHC was significantly lower than that in LC and controls;the serum IL-18BP in PHC was significantly higher than that in LC and controls;the IL-18 and IL-18BP in LC were significantly higher than those in controls(P

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