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ObjectiveTo compare the differences in thyroid hormone levels between adolescents with and without suicidal ideation， and to explore the association between thyroid hormone/suicidal ideation and the antidepressant treatment. MethodsA total of 100 patients were divided into non-suicidal ideation group and suicidal ideation group according to the SIOSS. The levels of thyroid-stimulating hormone （TSH）， triiodothyronine （T3）， thyroxine （T4）， free triiodothyronine （FT3） and free thyroxine （FT4） were compared between the two groups as well as their changes after 6 weeks of antidepressant treatment. ResultsThe levels of FT3， FT4 and T4 in the non-suicidal ideation group were higher than those in the suicidal ideation group. After 6 weeks of antidepressant treatment， the levels of FT3， FT4 and T4 in the suicide ideation group were higher than those before the treatment. The FT3 level in the male non-suicidal ideation group was higher than that in the suicidal ideation group. The levels of FT4 and T4 in the female non-suicidal ideation group were higher than those in the suicidal ideation group （all P<0.05） ConclusionThere are differences in thyroid hormone levels between adolescents with and without suicidal ideation （both with first-episode depression）， and patients with suicidal ideation have significant changes after treatment with antidepressants.
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Objective:To explore the chain mediating effect of emotion dysregulation and trait anger between childhood trauma and aggressive behavior in adolescents.Methods:A sample of 1 333 undergraduates were recruited to complete the questionnaires about childhood trauma, aggressive behavior, emotion dysregulation, trait anger.The SPSS 23. 0 and Mplus 8.3 software were used to analysis data and test intermediate effect.Results:The scores of childhood trauma, aggressive behavior, difficulties in emotion regulation and trait anger were (33.624±8.211), (53.995±12.307), (91.781±17.518), (23.352±5.477), respectively. Correlation analysis showed that childhood trauma, aggressive behavior, emotion dysregulation and trait anger were positively correlated with each other( r=0.209-0.614; all P<0.01). Mediation modeling analysis showed that childhood trauma had a significant direct effect on aggressive behavior. The direct effect value was 0.121, accounting for 35.8% of the total effect. The total indirect effect of childhood trauma on aggressive behavior was 0.217, accounting for 64.2% of the total effect. The mediating effect of emotion dysregulation as mediator between childhood trauma and aggressive behavior was 0.035, accounting for 10.4% of the total effect. The mediating effect of trait anger as mediator between childhood trauma and aggressive behavior was 0.108, accounting for 31.9% of the total effect. The chain mediating effect of emotion dysregulation and trait anger was 0.074, accounting for 21.9% of the total effect. Conclusion:Emotion dysregulation and trait anger exert a multiple mediating effect on the relationship between childhood trauma and aggressive behavior.
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Necroptosis,it is activated by the formation of necrosome,is a way of programmed cell death that independent of the activation of caspase.Necroptosis is regulated by many factors,for example,RIPK1 can initiate necroptosis,but also inhibit necroptosis;caspase-8 is the key negative regulation factor of necroptosis;CHIP is a new regulation protein of necroptosis.Triggering necroptosis is a promising strategy to overcome apoptosis resistance in cancer.