Magnet Quench Factors in Ramping-up Procedure / 中国医疗器械杂志

Ramping-up is the magnet current injection procedure which is under the control of resistance, voltage, current lead temperature, magnet pressure, temperature and so on. In this procedure, the factors related to the stability of the magnet such as, magnet temperature, pressure and currents are constantly changing. This procedure is the main step which the magnet-quench occurs in. This study uses the data collected during 7 years and SIMENS MRI ramping-up theory, in order to help engineers understand the key factors to reduce the magnet quench during the ramping up procedure.

Effect of etoricoxib on IL-1βand TNF-αwith gouty arthritis / 中国生化药物杂志

Objective To study effect of etoricoxib on IL-1βand TNF-αin patients with gouty arthritis.Methods 86 patients with gouty arthritis from July 2014 to July 2016 in our hospital were selected, all patients were divided into study group and control group according to the treatment method with 43 cases in each group.The patients in the control group were treated with diclofenac sodium, the patients in the study group were treated with etoricoxib.The clinical symptoms, clinical treatment effects, VAS score, serum IL-1β, TNF-αlevels and adverse reactions were observed and compared between the two groups.Results The VAS score, the joint swelling score and the mobility limitation score of the study group were decreased than before treatment and significantly lower than those of the control group, the difference was statistically significant (P<0.05).The effective rate of the study group (95.35%) was significantly higher than that of the control group (79.07%), the difference was statistically significant(P<0.05).The levels of IL-1βand TNF-αin the two groups were significantly lower than before treatment and the levels of IL-1βand TNF-αin the study groups were significantly lower than those in the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the study group was lower than that in the control group, the difference was statistically significant(P<0.05).Conclusion The clinical efficacy of etoricoxib in treating patients with gouty arthritis is significant, which can effectively relieve the clinical symptoms, inhibit the expression of IL-1βand TNF-α, and the adverse reactions less.

Effect of domperidone on enhancement of colonic motor activity / 中华消化杂志

Objective To observe the prokinetic effect of domperidone on colon and compare with that of mosapride and cisapride.Methods ① In viva experiment:forty rats were divided into control,domperidone,mosapride,and cisapride groups with 10 in each group.Stran gauges were planted both in proximal and distal colons and colonic motor activities were recoded in conscious rats.② In vitro experiment:the prokinetics effects of dopamine or dopamine combined with domperidone on the contraction of isolated rat colon strips were recorded by tone-transducers in the thermostatic muscle bath.Results In viva experiments:① in the interdigestive period of resting,activities of rhythimic phasic contraction were recoded in colon at conscious rats,and ② it had been showed that dornperidone significantly enhanced the contraction of colon in dose-dependent manner.Compared with control group,the mean contraction amplitude of proximal colon and distal colon increased by 84.61% ± 7.26% and 76.37 % ± 8.47% in domeridone group,respectively,which was higher than those in mosapride group (50.32%±8.16% and 45.13%±7.16%,respectively),but as same as those in cisapride group (92.55% ± 8.37% and 81.27% ± 9.95%,respectively).In vitro experiments:① perfusion of dopamin (40 mg/ml) could significantly decrease the contraction of isolated colon strip by 91.56% ± 10.24% in comparison with Krebs-Ringer solution,and ① domperidone could block the relaxant effect of dopamin on the isolated colon strip.Conclusions Domperidone can significantly enhance the colonic motor activities via antidopaminergic action.The effects of domperidone are similar as eisapride and greater than mosapride.

The enhancement effect of domperidene on esophagus and lower esophageal sphincter / 中华消化杂志

Objective To observe the prokinetic effect of domperidone on esophagus and lower esophageal sphincter (LES), and compare its effect with that of mosapride and cisapride. Methods In vivo experiments: forty rats were divided into control, domperidone, mosapride, and eisapride groups. Strain gauges were planted in proximal esophagus, distal esophagus and LES to record the activities of esophagus and LES in conscious rat. In vitro experiments: in the thermostatic muscle bath, the prokinetic effect of domperidone, mosapride, and cisapride on the contractility of rat muscle strips from esophagus body and LES were recorded by tone-transducers. Results In vivo experiments, ① In the interdigestive period of resting conscious rats, only mild contraction activities were recoded in esophagus bodies. In LES, typical interdigestive migrating motor complex (MMC) with phase Ⅰ,Ⅱ,Ⅲ,and Ⅳ was recorded. The contraction amplitude of LES was much greater than esophagus body. ② Domperidone significantly enhanced the contraction of esophagus body and LES. The mean contraction amplitude of proximal esophagus, distal esophagus, and LES increased by 63.24%±7.17%, 75.54%±5.27%, and 85.81%±6.02%, respectively, compared with controls. The prokinetic effect showed a dose-effect relation. Mosapride at the same dosage increased the mean contraction amplitude of proximal esophagus, distal esophagus, and LES by 29. 71%±4.15%, 40.15%±3.30%, and 35.24%±5.36%, respectively, compared with controls. The prokinetic effects of mosapride on esophagus and LES were much less than domperidone. Cisapride at the same dosage increased the mean contraction amplitude of proximal esophagus, distal esophagus, and LES by 59.84%±6.55%, 70.11%±5.62%, and 75.13%± 5.10%, respectively, compared with controls. The prokinetic effects of cisapride were similar as domperidone. In vitro experiments. ① Domperidone perfusion could significantly increase the contraction of esophagus body and LES muscle strips by 87.74%±7.65% and 92.44±7.17%, respectively, compared with Krebs-Ringer (KR) solution perfuslon. Mosapride at the same dosage increased the mean contraction amplitude by 35.42%±5.02% and 31.12%±4.32%, respectively, compared with KR controls. The prokinetic effects of mosapride were much less than domperidone. Cisapride of the same dosage showed a similar prokinetic effect as domperidone. ② Atropine and tetrodotoxin could block the prokinetic effects of domperidone on esophagus and LES. Conclusions Domperidone can significantly enhance the esophagus body contraction and LES motility. The effects of domperidone are similar as cisapride and much greater than mosapride. The prokinetic effects of domperidone on esophagus and LES are not only through well-known dopaminergic receptor blockade, but also through the cholinergic nerves of the enteric nervous system.

The hydrophilicity and cell affinity of polylactic acid containg bionic function group of phosphorylcholine / 生物医学工程学杂志

A series of novel biodegradable and bionic functional polymers, PLLA-PC-PLLA, were synthesized using L-lactide ring-opening polymerization by L-a-Glycerophosphorylcholine (PC) from nature source. The hydrophilicity of the polymers was investigated. The results made known that, as PC group was brought into the backbone of PLLA, PLLA-PC-PLLA gained much better hydrophilicity than did PLLA, and polar phosphatidylcholines probably transferred to the sample surface in aqueous environment. The relative growth ratios of ECV304 cells to the lixivium of all PLLA-PC-PLLA were higher than 84% in 5 d culture. The cells adhesion of ECV304 on the films of PLLA-PC-PLLA lagged as compared to that on PLLA, but they could proliferate and cover the films in total. The difference between PLLA-PC-PLLA and PLLA was due to the existence of PC group. Thus, PLLA-PC-PLLA, the same as PLLA, are not cytotoxic, and ECV304 can attach and proliferate on them. PLLA-PC-PLLA have potential applications in the fields of tissue engineering and drug delivery system.

Self-assembled monolayers as model systems to study the relation between biocompatibity and surface chemistry of biomaterials / 生物医学工程学杂志

The surface properties of biomaterials are essentially important to their biocompatibility. The complexity of surface composition and structure of biomaterials bring out the problem that it is difficult to make fully clear how the surface chemical properties and the structures of biomaterials control the biological reactions between the surfaces and proteins and/or cells. The structure of self-assembled monolayers (SAMs) is well established and SAMs have the characteristics of which a variety of functional groups and molecules can be introduced, either before or after the monolayer is formed, and diversified spectroscopy monitoring can be used to characterize SAMs and changes after their interactions with proteins or cells. Thus, SAMs are suitable model substrates for the study of the relationship between the surface chemical properties and biocompatibility of biomaterials. This paper reviews the researches on SAMs as models to study the absorption of proteins, cell adhesion and proliferation on materials, and the influences of both surface chemical functional groups and motion of molecular chains on hemocompatibility of biomaterials.

Application of Combined Detection of Fecal Pathogens in Infantile Diarrhea / 中华医院感染学杂志

OBJECTIVE To investigate the application value of combined detection of fecal pathogens in infantile diarrhea.METHODS The Escherichia coli was detected by potato-dextrose agar(PDA) medium method and serum agglutination test was used to determine the serotype.The rotavirus,enteric adenovirus and Campylobacter jejuni were detected with latex agglutination test antigens.RESULTS Among the diarrhea children,the detection rate of rotavirus,C.jejuni to their,E.coli 1.5%,and adenovirus was 33.0%,7.2%,1.5% and 0.7%,respectively.The proportion of male and female detected positive was 1.6∶1.CONCLUSIONS The main etiologies of infantile infectious diarrhea are rotavirus and C.jejuni.The infection rate of E.coli and enteric adenovirus is lower.Therefore,combined detection of pathogens causing diarrhea is valuable to diagnose the infantile diarrhea.

Role of the area postrema of medulla oblongata in the regulation of canine interdigestive migrating motor complex / 中华医学杂志(英文版)

<p><b>OBJECTIVE</b>To determine the effect of the area postrema (AP) of the medulla oblongata on gastrointestinal interdigestive migrating motor complex (MMC) and the plasma motilin level.</p><p><b>METHODS</b>Interdigestive MMC activities of the antrum and duodenum were recorded by strain gauge implanted on the serosa of 8 conscious dogs. A cannula was intubated in femoral vein for motilin injection. The plasma motilin concentration was measured by RIA. We observed: (1) normal interdigestive MMC activity and fluctuations in plasma motilin concentration; (2) the effects of electrically damaging the AP on MMC activity and plasma motilin level; (3) whether intravenous injection of motilin could induce phase III contractions after the AP was destroyed.</p><p><b>RESULTS</b>(1) Typical interdigestive MMC with phase I, II, III, and IV was recorded in normal dogs. Phase III was concurrent with the peak of plasma motilin level. (2) In damaged AP dogs, antroduodenal interdigestive MMC contractions were suppressed; cyclic, phasic and migratory pattern of MMC was disrupted. Plasma motilin concentration was decreased. Intravenous injection of motilin could not induce phase III contractions.</p><p><b>CONCLUSIONS</b>The area postrema might play an important role, which is mediated by motilin, on the regulation of interdigestive MMC.</p>

AN ANALYSIS OF PRE-OPERATIVE RADIOTHERAPY ON 51 CASES OF NON-SMALL CELL LUNG CANCER (NSCLC) / 中华放射肿瘤学杂志

0.05). The 1,3 and 5-year regional control and survival rates in both groups were concordant, demonstrating that the prognosis of these two groups was similar. The 5-year survival rate in pre-operative radiotherapy group was 37%. The results of retrospective analysis by Log-rank and Cox proportional regression methods demonstrated that whether the tumor resected or not were the major factors affecting pre-operative radiotherapy effect.