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Objective To study the value of the diameters of fetal umbilical artery and umbilical vein in early prenatal screening program for thalassemia by ultrasound.Methods A total of 120 cases of singleton pregnant with thalassemia at 12- 28 gestational weeks were detected by ultrasound,328 cases of normal singleton pregnant at 12 - 28 gestational weeks were selected as controls.The diameters of fetal umbilical artery and umbilical vein were tested and compared between the two groups.The diagnostic values were evaluated by ROC curve.Results At 12 - 15+6 gestational weeks,the diameters of umbilical artery and umbilical vein of thalassemia group were larger than those of control group(P ＜0.05).At 16 - 19+6 gestational weeks, the diameter of umbilical vein of thalassemia group was larger than that of control group,the differences were significant (P ＜0.05).The cutoff threshold of the diameter of fetal umbilical artery was 1.80 mm,the diameter of fetal umbilical vein was 2.95 mm at 12 - 15+6 gestational weeks,the diameter of fetal umbilical vein was 3.80 mm at 16- 19+6 gestational weeks,which were obtained by ROC analysis.The sensitivity of this cutoff threshold to identify thalassemia were 83.3％, 83.3％, 47.8％,respectively, while the specificity were 90.5 ％, 95.2 ％, 85.4％, respectively.Conclusions The diameters of fetal umbilical artery and umbilical vein detected by ultrasound have great value on early prenatal screening of thalassemia, these indexes can be used as an important factors in early prenatal screening of thalassemia.
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Objective To explore the relationship between the QT dispersion in simple central obesity youth and carotid atherosclerosis. Methods 38 patients with simple central obesity (obesity group) aged from 18 to 35 years, and 34 normal weight healthy control subjects (control group), age-matched were chosen. The blood pres-sure(BP) ,body mass index(BMI) ,waist-hip ratio(WHR) ,QTd,QTcd,plus the ultrasound examination of the inti-ma-media thickness(IMT) of carotid were measured and plaques on the patients' carotid artery were detected. Re-sults Comparing to the control group,BP,BMI,WHR,QTd,QTcd were larger in the obesity group with significant difference (P < 0.05) ; When QT dispersion was > 50 ms, the risk of IMT was higher than that when QT dispersion was < 50 ms (OR = 7.0,P < 0.05). Condnsion In the youth who are simple central obesity, their QT disper-sions are over the normal reference value, intima-media thickness are abnormal; the risk of IMT is higher when QT dispersion is > 50 ms; suggesting that QT dispersion can be one of reference index for forecasting the cardiovascular disease.
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Objective To investigate the relationship between carotid artery intima-media thickness(IMT) and blood pressure(BP) as well as QT dispersion in 18 - 35 young people. Methods Body mass index (BMI) and BP of 107 people in 18 - 35 years of age were measured, the carotid artery was also detected by 2-dimensional and color Doppler ultrasound. According to BMI,a]I candidates were divided into group A(norrnal BMI) and group B(obesity), then the relationship between IMT and BP, QT dispersion were analyzed. Results Compared with group A,BP,IMT,QT dispersion in group B were increased, there was significant diference between the two group (P <0.05). Relationship was positive correlative between IMT and systolic BP(LIMT: r=0.224, P=0.021;RIMT:r=0.193,P=0.047) ,but negative correlative between IMT and diastolic BP(LIMT: r=0.123, P=0.210; RIMT: r=0.138, P=0.159). The risk estimate of abnormal IMT was higher when QT dispersion >50 ms than that ≤50 ms(OR=6.223, P<0.05). Conclusions The systolic BP is positive correlative with IMT of carotid artery at age 18-35,increasing QT dispersion is a high risk factor of abnormal IMT. IMT should be detected when QT dispersion >50 ms and systolic BP >120 mm Hg.