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<p><b>OBJECTIVE</b>To explore the incidence of HBsAg and the risk of HBV infection in patients with multiple myeloma (MM).</p><p><b>METHODS</b>A total of 114 newly diagnosed MM patients admitted in our hospital from May 2014 to July 2016 were enrolled in MM group, 110 healthy persons were enrolled in control group. The HBsAg positive rate and HBV infection rate were compared between 2 groups; the HBV infection rate of MM patients was compared before and after chemotherapy. According to detected results, all patients were divided into HBsAggroup and HBsAggroup, and the lever damage in 2 groups was compared before and after treatment. For HBsAgand HBV-DNApatients, the preventive antiviral treatment was performed, while for other patients the preventive antiviral treatment was not performed, then the HBV reactivation was tested in each group.</p><p><b>RESULTS</b>The incidence of HBsAgin MM patients seem a litter higher than that in control group without statistical significance (P>0.05); the incidence and severity of HBsAggroup were higher than those of control group before treatment, moreover the difference between 2 groups was more significant after treatment (P< 0.05). The HBsAg reactivation was not found in 4 pases with HBsAgwho received the proventive antiviral treatment, while the HBsAg reactivation was observed in 2 cases out of 6 cases without proventive antiviral treatment; the HBsAg reactivation happened only in 1 case of HBsAggroup after treatment. The HBV infection rate in MM patients after chemotherapy was significantly enhenced as compared with infection rate before chemotherapy(P< 0.05).</p><p><b>CONCLUSION</b>The HBV infection rate in MM patients is higher than that in normal persons, moreover tha HBV-reactivation may happen in patients with ocult HBV infection in process of treatment; the HBV infection correlates with MM to a certain degree. The monitoring HBsAg for MM patients contributes to evaluation of liver danage.</p>
RESUMO
<p><b>OBJECTIVE</b>To compare the efficacy differences between integrative therapy of electroacupuncture and repetitive transcranial magnetic stimulation (rTMS) and simple rTMS only in the treatment of comorbid anxiety and depression (CAD).</p><p><b>METHODS</b>Eighty-five cases of CAD were randomized into two groups. The observation group (40 cases) was treated with electroacupuncture at Baihui (GV 20), Yintang (EX-HN 3), Shenting (GV 24), Shenmen (HT 7) and Neiguan (PC 6) mainly, combined with rTMS. The control group (45 cases) was treated with simple rTMS. Separately, before treatment, after 5 days and 10 days treatment, Hemilton Depression Scale (HAMD) and Hemilton Anxiety Scale (HAMA) were used for the scoring of depression and anxiety. Additionally, the efficacies were compared between two groups.</p><p><b>RESULTS</b>After 5 days, 10 days treatment, the scores of HAMA, HAMD were reduced remarkably as compared with those before treatment in two groups (all P < 0.001), HAMA score in observation group was lower than that in control group after 10 days treatment (P < 0.05). The remarkable effective rates of depression and anxiety in observation group those 10 days that treatment were 87. 1% (27/31) and 90.3% (28/31) respectively, which were higher apparently than 61.8% (21/34) and 61.8% (21/34) in control group separately (both P < 0.05).</p><p><b>CONCLUSION</b>The integrative therapy of electroacupuncture and rTMS is definitely effective on CAD. This method is better than simple rTMS.</p>