RESUMO
Objective:To initially investigate whether simultaneous radiochemotherapy with hyperthermia can prolong the survival of glioblastoma (GBM) patients.Methods:Clinical data of 61 GBM patients undergoing surgery in our hospital from September 2016 to June 2019 were retrospectively analyzed. According to different treatment methods, all patients were divided into the control group ( n=34) and observation group ( n=27). In the control group, three-dimensional radiotherapy with a dose of 60 Gy combined with temoazolamine chemotherapy was delivered. In the observation group, simultaneous radiochemotherapy with 15-20 cycles of hyperthermia at 40-41℃ was supplemented. The survival time was calculated by Kaplan-Meier method, and the survival time was compared with log-rank test between two groups. Results:The median progression-free survival in the observation group was significantly longer than that in the control group (14.33 months vs.9.94 months, P<0.05). The median overall survival in the observation group was also remarkably higher than that in the control group (18 months vs. 14 months, P<0.05). Conclusions:Simultaneous radiochemotherapy with hyperthermia is innovatively applied to treat GBM after surgical resection. Preliminary findings demonstrate that compared with chemoradiotherapy, simultaneous radiochemotherapy with hyperthermia can prolong the survival time of GBM patients.
RESUMO
Objective:To investigate the association between the cerebral microbleeds(CMBs)and CHA 2DS 2-VASc score in patients with non-valvular atrial fibrillation(NVAF), and to analyze the related risk factors for CMBs. Method:This was a retrospective case-control study.A total of 164 patients with NVAF who had performed brain magnetic resonance susceptibility weighted imaging in Zhejiang Hospital from January 2015 to December 2017 were included.Based on the presence of CMBs, all patients were divided into the CMBs group(n=43, 26.2%)and the non-CMBs group(n=121, 73.8%). We collected the data about clinical characteristics, CHA2DS2-VASc score and number of CMBs.The association between CMBs and CHA2DS2-VASc score was analyzed by Spearman linear test.The Logistic regression analyses was used to evaluate the association between CMBs and the risk factors, including age, hypertension, etc.Results:The incidence of CMBs was markedly increased with the increase of CHA 2DS 2-VASc score( P<0.05). Besides, the rate of CMBs ≥5 was also positively associated with CHA 2DS 2-VASc score( P<0.05). Patients in the CMBs group was significantly older than those in the non-CMBs group[(81.0±8.1)years vs.(75.4±11.2)years, P<0.01]. There were significantly differences in rates of hypertension(83.7% vs. 63.2%), moderate-severe leukoaraiosis(44.2% vs.33.9%), anticoagulant therapy(34.9% vs.19.0%)and median CHA 2DS 2-VASc score(4 vs.3)between the CMBs group and the non-CMBs group(all P<0.05). Logistic regression analyses showed that age and anticoagulant therapy were the independent risk factors of CMBs in NVAF patients(all P<0.05). Conclusion:CMBs is strongly associated with CHA 2DS 2-VASc score in patients with NVAF.Age and anticoagulant therapy are its independent risk factors.It is necessary to detect the possibility of CMBs in old NVAF patients with high CHA 2DS 2-VASc score before and during anticoagulant therapy.
RESUMO
BACKGROUND AND PURPOSE: The objective of this study was to determine the prevalence of and risk factors for dementia in residents aged 65 years and older in a Chinese nursing home. METHODS: A cross-sectional study was carried out in a nursing home located in Hangzhou, Zhejiang Province, China. Cognitive status, including the presence of dementia and mild cognitive impairment (MCI), was measured using a combination of medical history and objective cognitive assessments. Logistic regression analysis was conducted to predict the associated risk factors. RESULTS: In total, 943 residents (334 males and 609 females) aged 84.00±6.67 years (mean±SD) were included. Dementia was diagnosed in 420 (44.5%) residents, and MCI was diagnosed in 195 (20.7%). Mild, moderate, and severe dementia were present in 20.3%, 14.0%, and 65.7% of those in the dementia group, respectively. Logistic regression analysis revealed that dementia was associated with a low education level (p=0.000), an advanced age (p=0.010), and a history of stroke (p=0.023). CONCLUSIONS: Our study found a high prevalence of dementia in a Chinese nursing home, and a high prevalence of patients with severe dementia. Risk factors for dementia included a low educational level, an advanced age, and a history of stroke. Appropriate interventions need to be applied to this population.