Iodine nutrition status of pregnant women in Ningxia Hui Autonomous Region from 2017 to 2020 / 中华地方病学杂志

Objective:To analyze and compare the salt iodine content and iodine nutrition status of pregnant women in Ningxia Hui Autonomous Region (Ningxia for short), and to provide basis for formulation of prevention and control measures.Methods:From 2017 to 2020, 100 pregnant women were surveyed each year in 22 counties (cities, districts) in Yinchuan, Shizuishan, Wuzhong, Guyuan and Zhongwei of Ningxia, salt samples and urine samples were collected for salt iodine and urinary iodine detection.Results:Totally 8 807 salt samples were collected, the median salt iodine was 24.6 mg/kg. The qualified rate of iodized salt was 91.59% (7 838/8 558), the coverage rate of iodized salt was 97.17% (8 558/8 807), and the consumption rate of qualified iodized salt was 89.00% (7 838/8 807). The consumption rate of qualified iodized salt increased year by year (χ 2trend = 248.47, P < 0.001). There were statistical differences in salt iodine levels in different years and regions ( H = 259.14, 37.09, P < 0.001). Totally 8 107 urine samples were collected, the median urinary iodine of pregnant women was 165.00 μg/L, which reached the appropriate level. The median and composition of urinary iodine were statistically different in different regions and pregnancies ( H = 28.87, 17.91, P < 0.001; χ 2 = 85.89, 20.59, P < 0.05). Conclusions:The coverage rate of iodized salt among pregnant women in Ningxia is high, and the urinary iodine level is generally in a suitable state. However, for pregnant women at risk of iodine deficiency, special attention should be paid and targeted iodine supplementation measures should be taken.

Site-directed mutagenesis enhances the activity of benzylidene acetone synthase of polyketide synthase from Polygonum cuspidatum / 生物工程学报

Polygonum cuspidatum polyketide synthase 1 (PcPKS1) has the catalytic activity of chalcone synthase (CHS) and benzylidene acetone synthase (BAS), which can catalyze the production of polyketides naringenin chalcone and benzylidene acetone, and then catalyze the synthesis of flavonoids or benzylidene acetone. In this study, three amino acid sites (Thr133, Ser134, Ser33) that may affect the function of PcPKS1 were identified by analyzing the sequences of PcPKS1, the BAS from Rheum palmatum and the CHS from Arabidopsis thaliana, as well as the conformation of the catalytic site of the enzyme. Molecular modification of PcPKS1 was carried out by site-directed mutagenesis, and two mutants were successfully obtained. The in vitro enzymatic reactions were carried out, and the differences in activity were detected by high performance liquid chromatography (HPLC). Finally, mutants T133LS134A and S339V with bifunctional activity were obtained. In addition to bifunctional activities of BAS and CHS, the modified PcPKS1 had much higher BAS activity than that of the wild type PcPKS1 under the conditions of pH 7.0 and pH 9.0, respectively. It provides a theoretical basis for future use of PcPKS1 in genetic engineering to regulate the biosynthesis of flavonoids and raspberry ketones.

Risk factors and countermeasures of depression in acute stroke patients in Wuhan / 公共卫生与预防医学

Objective To explore the risk factors and countermeasures of depression in stroke patients in Wuhan. Methods A stratified cluster sampling method was used to randomly select 628 hospitalized patients at acute stage of stroke in Wuhan from June 2019 to June 2020. According to HAMD score, the patients were divided into normal group (n=381) and post-stroke depression group (n=247). The risk factors of depression in stroke patients were analyzed by Logistic regression using self-made questionnaire, including gender, age, education level, stroke type, residence, patient compliance to treatment, NIHSS score, ADL score and independent walking, and early intervention measures were proposed. Results Univariate analysis showed that education level, family burden, NIHSS score, ADL score and independent walking were related to the occurrence of depression in stroke patients (P<0.05). Logistic multivariate regression analysis showed that, NIHSS score, ADL score and independent walking were correlated with depression in patients at acute stage after stroke (P<0.05). Conclusion the risk of depression in patients with acute cerebral apoplexy is higher, the patients' adherence to treatment, NIHSS score, ADL scores, situation of independent walking is a cause of depression in patients with cerebral apoplexy risk factors, should improve patients' adherence to treatment as soon as possible and daily life ability, improve nerve function, should pay attention to its early intervention.

Constructing a scale on KAP of nurses ′ on stroke-dysphagia and test of its reliability and validity / 中国实用护理杂志

Objective:To develop a rating scale on the knowledge, attitude and practice of stroke-dysphagia for nurses, and to test the reliability and validity.Methods:Based on theoretical framework of the Knowledge, Attitude, Practice (KAP), the scale items were determined through literature review, expert consultation, pre-investigation, and qualitative interviews. 633 nurses in the department of stroke that from 18 hospitals in Hubei Province were selected for the survey, to further screen the items and test reliability and validity of the scale.Results:The positive coefficient of the two-round expert consultation were both 100%; the expert authority coefficient was 0.930; the level of coordination of experts ′ opinions was good. Exploratory factor analysis extracted 4 factors, the accumulative variance contribution rate was 44.278%, Content validity index S-CVI was 0.984, I-CVI was 0.857-1.000; the Cronbach α coefficient of scale was 0.855, test-retest reliability was 0.909. Eventually, the scale was consisted of 3 dimensions, 32 items. Conclusion:The scale has good reliability and validity, and can be used as a survey tool to test the current knowledge, attitude, practice of clinical nurses about patient with stroke-dysphagia.

The Progression of SARS Coronavirus 2 (SARS-CoV2): Mutation in the Receptor Binding Domain of Spike Gene

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) is a positive-sense singlestranded RNA (+ssRNA) that causes coronavirus disease 2019 (COVID-19). The viral genome encodes twelve genes for viral replication and infection. The third open reading frame is the spike (S) gene that encodes for the spike glycoprotein interacting with specific cell surface receptor – angiotensin converting enzyme 2 (ACE2) – on the host cell membrane. Most recent studies identified a single point mutation in S gene. A single point mutation in S gene leading to an amino acid substitution at codon 614 from an aspartic acid 614 into glycine (D614G) resulted in greater infectivity compared to the wild type SARS-CoV2. We were interested in investigating the mutation region of S gene of SARS-CoV2 from Korean COVID-19 patients. New mutation sites were found in the critical receptor binding domain (RBD) of S gene, which is adjacent to the aforementioned D614G mutation residue. This specific sequence data demonstrated the active progression of SARS-CoV2 by mutations in the RBD of S gene.The sequence information of new mutations is critical to the development of recombinant SARS-CoV2 spike antigens, which may be required to improve and advance the strategy against a wide range of possible SARS-CoV2 mutations.

The Progression of SARS Coronavirus 2 (SARS-CoV2): Mutation in the Receptor Binding Domain of Spike Gene

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) is a positive-sense singlestranded RNA (+ssRNA) that causes coronavirus disease 2019 (COVID-19). The viral genome encodes twelve genes for viral replication and infection. The third open reading frame is the spike (S) gene that encodes for the spike glycoprotein interacting with specific cell surface receptor – angiotensin converting enzyme 2 (ACE2) – on the host cell membrane. Most recent studies identified a single point mutation in S gene. A single point mutation in S gene leading to an amino acid substitution at codon 614 from an aspartic acid 614 into glycine (D614G) resulted in greater infectivity compared to the wild type SARS-CoV2. We were interested in investigating the mutation region of S gene of SARS-CoV2 from Korean COVID-19 patients. New mutation sites were found in the critical receptor binding domain (RBD) of S gene, which is adjacent to the aforementioned D614G mutation residue. This specific sequence data demonstrated the active progression of SARS-CoV2 by mutations in the RBD of S gene.The sequence information of new mutations is critical to the development of recombinant SARS-CoV2 spike antigens, which may be required to improve and advance the strategy against a wide range of possible SARS-CoV2 mutations.

Clinical observation of cluster sedation and analgesia for patients with mechanical ventilation / 中国基层医药

Objective To investigate the effect of cluster sedation and analgesia for patients with mechanical ventilation.Methods From June 2016 to June 2017,234 patients with mechanical ventilation admitted to the ICU of the Second Hospital of Jiaxing were selected and divided into study group (120 cases) and control group (114 cases) according to the random number method.The control group received conventional nursing ,while the study group was given cluster sedation and analgesia.The drug use dose,mechanical ventilation time ,ICU admission time, sputum incidence and 1－month survival rate were compared between the two groups.Results The total dose and unit dose in the study group were lower than those in the control group [(252.17 ±38.42) mg vs.(326.50 ±50.88) mg, (60.50 ±9.33)μg· kg －1· h－1 vs.(79.41 ±10.52)μg· kg－1· h－1 ,t＝12.562,14.564,P＝0.000,0.000].The duration of mechanical ventilation and ICU stay in the study group were also shorter than those in the control group [(5.13 ±0.73)d vs.(7.57 ±0.95) d,(7.02 ±0.91) d vs.(10.55 ±1.26) d,t＝21.949,24.460,P＝0.000, 0.000].The incidence rate of delirium in the study group was lower than that in the control group (28.33% vs. 50.88%,χ2 ＝12.453,P＝0.000).The 1－month survival rate of the study group was higher than that of the control group (91.67%vs.80.70%,χ2 ＝5.954,P＝0.015).Conclusion Cluster sedation and analgesia is an effective method for ICU mechanical ventilation patients , which can improve the quality of medical and nursing , and is an important embodiment in critical medical management ,it is worthy of attention in intensive care workers.

Clinical observation of cluster sedation and analgesia for patients with mechanical ventilation / 中国基层医药

Objective@#To investigate the effect of cluster sedation and analgesia for patients with mechanical ventilation.@*Methods@#From June 2016 to June 2017, 234 patients with mechanical ventilation admitted to the ICU of the Second Hospital of Jiaxing were selected and divided into study group (120 cases) and control group (114 cases) according to the random number method.The control group received conventional nursing, while the study group was given cluster sedation and analgesia.The drug use dose, mechanical ventilation time, ICU admission time, sputum incidence and 1-month survival rate were compared between the two groups.@*Results@#The total dose and unit dose in the study group were lower than those in the control group [(252.17±38.42)mg vs.(326.50±50.88)mg, (60.50±9.33)μg·kg-1·h-1 vs.(79.41±10.52)μg·kg-1·h-1, t=12.562, 14.564, P=0.000, 0.000]. The duration of mechanical ventilation and ICU stay in the study group were also shorter than those in the control group [(5.13±0.73)d vs.(7.57±0.95)d, (7.02±0.91)d vs.(10.55±1.26)d, t=21.949, 24.460, P=0.000, 0.000]. The incidence rate of delirium in the study group was lower than that in the control group (28.33% vs.50.88%, χ2=12.453, P=0.000). The 1-month survival rate of the study group was higher than that of the control group (91.67% vs.80.70%, χ2=5.954, P=0.015).@*Conclusion@#Cluster sedation and analgesia is an effective method for ICU mechanical ventilation patients, which can improve the quality of medical and nursing, and is an important embodiment in critical medical management, it is worthy of attention in intensive care workers.

Mediation of psychological vulnerability in the association between stressful life events and psychological crisis among college students / 中国学校卫生

Objective@#To explore the psychological vulnerability in the relationship between stressful life events and psychological crisis, and to provide basis for psychological crisis prevention among college students.@*Methods@#With stratified cluster sampling，3584 students in Weifang Medical University and Weifang University were selected for a crosssectional selfadministrated questionnaire survey in December 2017. A selfdesigned general questionnaire, Adolescent SelfRating Life Events Check List(ASLEC), psychological vulnerability scale, and psychological crisis performance questionnaire for college students were applied in the survey. Mediating effect was tested by using SPSS 23.0 and AMOS 23.0.@*Results@#The average score was 36.53±8.58 for life events(ASLEC), 54.21±11.80 for psychological vulnerability,and 26.33±39.72 for psychological crisis performance. The life events score was positively correlated with psychological crisis score (r=0.54, P<0.05) and positively correlated with psychological vulnerability score(r=0.30, P<0.05); psychological vulnerability score was positively correlated with psychological crisis score(r=0.37, P<0.05). Psychological vulnerability played a partial intermediary role on the relationship between life events and psychological among undergraduates,the effect was 0.10 accounting for 15.13% of the total effect.@*Conclusion@#Life events have made a direct influence and an indirect influence mediated by psychological crisis vulnerability on psychological crisis among undergraduates.

Analysis of investigation results of iodine content of drinking water of residents in Ningxia Hui Autonomous Region in 2017 / 中华地方病学杂志

Objective To understand the iodine content of drinking water in Ningxia,and provide a basis for promoting scientific iodine supplementation.Methods In 2017,22 counties (cities,districts) of Ningxia Hui Autonomous Region were surveyed by township (town,street office) as the unit.Water samples were collected and iodine content was detected according to the unified centralized water supply,mixed water supply and all the scattered water supply methods.Among them,the investigation at township (town and street office) level found that the median of iodine in water was ＞ 10 μg/L,and then the water samples were collected in administrative villages (neighborhood committees) and the content of iodine in water was detected.Results A total of 242 townships (town,street office) were surveyed at the township level water iodine,and a total of 1 048 water samples were collected,the median water iodine was 6.6 μg/L,the range was 0.0-97.8 μg/L.There were 75 townships with a median water iodine ＞ 10 μg/L,and an administrative village level water iodine survey was conducted.A total of 1 169 water samples were collected,the median water iodine was 14.5 μg/L,and the range was 0.0-97.4 μg/L.The median water iodine at the township level,unified centralized water supply,mixed water supply,and all the scattered water supply was 6.9,6.8,and 4.5 μg/L,respectively.The difference was statistically significant (x2 =7.08,P ＜ 0.05).The median water iodine at the administrative village level,unified centralized water supply,mixed water supply,and all the scattered water supply was 15.8,8.4,and 11.6 μg/L,respectively.The difference was statistically significant (x2 =35.23,P ＜ 0.05).Conclusion The iodine content of drinking water in Ningxia residents is low,which is consistent with the fact that Ningxia is in the iodine deficient area.

Anxiety life interference among primary and middle school students in Henan Province and its influencing factors / 中国学校卫生

Objective@#To investigate anxiety life interference among primary and middle school students in Henan Province and its influencing factors, and to provide scientific basis for health education in primary and secondary school students.@*Methods@#By using cluster sampling method, 3 573 primary school students and 2 748 secondary school students in Henan Province were investigated with Child Anxiety Life Interference Scale(CALIS), Resilience Scale for Chinese Adolescents(RSCA), Perceived Social Support Scale(PSSS), Self-Esteem Scale(SES), General Self-efficacy Scale(GSES).@*Results@#There were significant differences in anxiety life disturbance in primary and middle school students by gender(t=2.07, P=0.04), school level(t=-2.29, P=0.02), degree of anxiety(F=119.93, P<0.01), educational level of fathers (F=13.38, P<0.01) and educational level of mothers(F=9.65, P<0.01). The degree of life disturbance caused by anxiety was negatively correlated with mental resilience, social support and self-efficacy(r=-0.25, -0.09, -0.12, P<0.01), and was positively related to self-esteem(r=0.23). Mental resilience (β=-0.21) significantly negatively predicted anxiety interference with life, while self-esteem (β=0.13) and social support (β=0.06) significantly positively predicted anxiety interference with life.@*Conclusion@#The life of primary and middle school students is seriously disturbed by anxiety, and mental resilience is the primary psychosocial factor that affects the level of anxiety life interference among primary and middle school students.

Analysis of investigation results of iodine content of drinking water of residents in Ningxia Hui Autonomous Region in 2017 / 中华地方病学杂志

Objective@#To understand the iodine content of drinking water in Ningxia, and provide a basis for promoting scientific iodine supplementation.@*Methods@#In 2017, 22 counties (cities, districts) of Ningxia Hui Autonomous Region were surveyed by township (town, street office) as the unit. Water samples were collected and iodine content was detected according to the unified centralized water supply, mixed water supply and all the scattered water supply methods. Among them, the investigation at township (town and street office) level found that the median of iodine in water was > 10 μg/L, and then the water samples were collected in administrative villages (neighborhood committees) and the content of iodine in water was detected.@*Results@#A total of 242 townships (town, street office) were surveyed at the township level water iodine, and a total of 1 048 water samples were collected, the median water iodine was 6.6 μg/L, the range was 0.0-97.8 μg/L. There were 75 townships with a median water iodine > 10 μg/L, and an administrative village level water iodine survey was conducted. A total of 1 169 water samples were collected, the median water iodine was 14.5 μg/L, and the range was 0.0-97.4 μg/L. The median water iodine at the township level, unified centralized water supply, mixed water supply, and all the scattered water supply was 6.9, 6.8, and 4.5 μg/L, respectively. The difference was statistically significant (χ2 = 7.08, P < 0.05). The median water iodine at the administrative village level, unified centralized water supply, mixed water supply, and all the scattered water supply was 15.8, 8.4, and 11.6 μg/L, respectively. The difference was statistically significant (χ2 = 35.23, P < 0.05).@*Conclusion@#The iodine content of drinking water in Ningxia residents is low, which is consistent with the fact that Ningxia is in the iodine deficient area.

Investigation on the significance of pressure pain thresholds before and after treatment in female with myofascial chronic pelvic pain / 中国医师进修杂志

Objective To explore the therapeutic effect and clinical significance of pelvic floor rehabilitation technique in female with myofascial chronic pelvic pain (MCPP) by detecting the pressure pain thresholds (PPTs). Methods One hundred healthy female (control group) and 324 female MCPP patients (observation group) from January 2009 to December 2016 were selected. Automatic body surface and vaginal pressure pain detector was applied to detect two groups′PPTs of the 34 spots. The difference of PPTs at each spot was analyzed in two groups. In addition, 51 patients with moderate and severe MCPP were selected to record the changes of PPTs and pain scores before and after the treatment of pelvic floor rehabilitation technique. Results The average PPTs of the abdomen, vulva, pelvic floor and vaginal front and back fornix, bilateral adnexa uteri and sacrouterine ligament in the observation group were significantly lower than those in the control group (P<0.01 or<0.05). The average PPTs of the abdomen, vulva, pelvic floor muscles and vaginal front and back fornix, bilateral adnexa uteri and sacrouterine ligament of 51 MCPP patients after treatment were significantly higher than those before treatment (P<0.01). After treatment, PPTs and pain scores of the pelvic floor muscles, bilateral adnexa uteri, bilateral sacrouterine ligament, bilateral sacral spine ligament and vaginal front and back fornix were negatively correlated (r =- 0.78 to- 0.19, P = 0.01 to 0.04); there was a negative correlation between the PPTs and pain scores of the left and right latissimus dorsi (r=-0.28, P=0.04;r=-0.32, P=0.02). The complete remission rate with the pelvic floor rehabilitation technique in 51 patients with MCPP was 9.8％(5/51), the significant remission rate was 90.2％(46/51), and the total remission rate was 100.0％ (51/51). Conclusions Compared with the normal healthy ones, female with MCPP has lower PPTs in the abdomen, perineum, vagina and pelvic floor. The effect of pelvic floor rehabilitation technique on MCPP is well, which can increase patients′PPTs to reduce pain scores. It is a worthwhile method to treat these diseases.

Study of Shenling-Baizhu granule combined with saccharomyces boulardii treatment for pediatric antibiotic associated diarrhea / 国际中医中药杂志

Objective To observe Shenling-Baizhu granule combined with saccharomyces boulardii treatment for pediatric antibiotic associated diarrhea (AAD). Methods A total of 146 children with AAD were randomly divided into the control group (n=73) and the observation group (n=73). The control group received the saccharomyces boulardii, and the observation group received saccharomyces boulardii and Shenling-Baizhu granule, with a course of 5 days. The CD4 and CD8 T lymphocytes were detected by flow cytometry. The stool frequency, stool frequency recovery time, and clinic effects were compared. Results The stool frequency (3.0 ± 0.4 times/d vs. 3.6 ± 0.4 times/d, t=2.624), stool frequency recovery time (3.2 ± 0.6 d vs. 4.5 ± 0.8 d, t=2.641), and recovery time (4.1 ± 0.8 d vs. 5.3 ± 1.1 d, t=2.522) in observation group were significantly lower than those in control group ( P＜0.05). After the treatment, the CD4+(38.65% ± 5.74% vs. 33.72% ± 5.23%, t=2.452), CD4+/CD8+(1.92 ± 0.38 vs. 1.45 ± 0.26, t=2.483) of the observation group was significantly higher than those of the control group, and the CD8+(20.15% ± 3.16% vs. 23.21% ± 3.44%, t=2.483) of the observation group was significantly lower than this of the control group (P＜0.05). The rate of clinic effects was 93.2% (68/73) in observation group, which was higher than 80.8% (59/73) in control group (χ2=2.446, P＜0.05). Conclusions The Shenling-Baizhu granule combined with saccharomyces boulardii could enhance the immune function in children with AAD with significant clinical efficacy.

Observation on therapeutic effect of application of aerosol inhalation of Scutellaria baicalensis in fine nursing care model for prevention of ventilator-associated pneumonia / 中国中西医结合急救杂志

Objective To approach the nursing experience and clinical therapeutic effect of using aerosol inhalation of Scutellaria baicalensis leachate to prevent occurrence of ventilator-associated pneumonia (VAP) in critically ill patients in intensive care unit (ICU). Methods Ninety-two severe patients who received mechanical ventilation (MV) in ICU of Hangzhou Geriatric Hospital from April 2016 to August 2017 were enrolled, and they were divided into a test group and a control group according to their wishes and self-selection, 46 cases in each group. The patients in both groups were given fine nursing care model, in the control group aerosol inhalation of physiological saline was used; in the test group aerosol inhalation of Scutellaria baicalensis leachate was applied. The incidence of VAP, the duration of MV and time of ICU stay were compared between the two groups. Results Compared to the control group, the total incidence of VAP, duration of MV, time of ICU stay in the test group were significantly lower than those in control group [total incidence of VAP: 17.39% (8/46) vs. 36.95% (17/46), duration of MV (days): 11.37±5.23 vs. 15.21±5.93, time of ICU stay (days): 18.54±5.92 vs. 27.33±5.27, all P < 0.05]. Conclusion Under the fine nursing care pattern, compared with the aerosol inhalation of saline, the aerosol inhalation of Scutellaria baicalensis leaching can be more effectively to prevent VAP in ICU critically ill patients and reduce their duration of MV and of ICU stay, so the latter one's clinical therapeutic effect is better.

The clinical application of laparoscopic common bile duct stone removal / 中华肝胆外科杂志

Cholecystolithiasis with choledocholithiasis (CCL) is a common disease.The removal of common bile stone is a challenge for the surgery.This paper discussed the clinical application of three stone removal techniques including direct stone removal,irrigation and stone extraction by basket under cholangioscopy in order to take the stones effectively and safely,shorten the procedure time,avoid the injuries of common bile duct wall caused by the repetition of a single method such as biliary endoscopic stone extraction,reduce the difficulty of taking stone and enhance recovery of patients.

Correlation analysis of serum cardiac troponin Ⅰ and clinical efficacy observation of Wushen decoction for treatment of patients with sepsis heart failure / 中国中西医结合急救杂志

Objective To investigate the effect of Wushen decoction on levels of serum cardiac troponin Ⅰ (cTnI),cardiac muscle enzyme and clinical parameters in patients with sepsis heart failure,and to analyze the correlations between cTnI and myocardial enzyme level and clinical parameters.Methods Forty-two patients diagnosed as sepsis admitted to Wuhan Hospital of Traditional Chinese Medicine from March 2014 to March 2016 were enrolled,and they were divided into a Wushen decoction treatment group and a control group by principle of single blind complete randomized method,21 cases in each group.The patients in control gToup were treated by conventional western medicine,while the patients in Wushen decoction treatment group,on the basis of conventional western medicine,they were treated additionally by Wushen decoction (composed of ginseng,radix sophorae flavescentis,radix glehniae,radix adenophorae,salvia,astragalus,notoginseng radix,rosewood,etc.),one dose a day,the therapeutic course in both groups being 7 days.The changes of biochemical indicators [cTnI,creatine kinase (CK),CK isoenzyme (CK-MB)],haemodynamics parameters [cardiac index (CI),central venous pressure (CVP),extravascular lung water index (ELWI),global ejection fraction (GEF),mean arterial pressure (MAP),heart rate (HR)],treatment condition and prognostic parameters [vasoactive drug dosage index,acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ) score,duration of mechanical ventilation,the length of stay in intensive care unit (ICU) and total hospitalization time] were compared before and after treatment for 7 days in the two groups.The correlations between the level of cTnI on admission before treatment and CK,CK-MB,APACHE Ⅱ,vasoactive drug dosage index,duration of mechanical ventilation,the length of stay in ICU and total hospitalization time were analyzed.Results The levels of cTnI,CK,CK-MB,CVP,ELWI,HR,vasoactive drug dosage index,APACHE Ⅱ score in two groups after treatment were obviously lower than those before treatment,the levels of CI,GEF,MAP were markedly higher than those before treatment,the duration of mechanical ventilation,the length of stay in ICU and total hospitalization time were significantly shorter than those before treatment,and the changes of above indexes were more remarkable in Wushen decoction group than those in control group [cTnI (mg/L):0.94-± 0.29 vs.1.30 ± 0.67,CK (U/L):96.00 ± 24.30 vs.101.38 ± 24.55,CK-MB (U/L):31.14 ± 6.78 vs.36.48 ± 8.17,CI (mL· s-1 · m-2):64.51 ± 5.83 vs.53.34 ± 4.67,CVP (cmH2O,1 cmH2O =0.098 kPa):10.56 ± 1.84 vs.11.94--2.16,ELWI (mL/kg):8.81±1.61 vs.11.66±2.30,GEF:(33.62±3.88)％ vs.(27.14±4.55)％,MAP (mmHg,1 mmHg =0.133 kPa):84.67 ± 5.58 vs.79.52 ± 5.74,HR (bpm):87.86 ± 9.02 vs.82.95 ± 5.26,vasoactive drug dosage index:2.44 ± 0.53 vs.2.89 ± 0.68,APACHE Ⅱ score:10.66 ± 1.66 vs.14.43 ± 1.82,duration of mechanical ventilation (days):1.67 ± 2.11 vs.2.10 ± 2.26,the length of stay in ICU (days):8.86 ± 2.59 vs.10.67 ± 2.96,total hospitalization time (days):13.24 ± 4.53vs.16.76 ± 5.04,all P ＜ 0.05].On admission before treatment,the correlations between the level of cTnI and CK,APACHE Ⅱ score,vasoactive drug dosage index,duration of mechanical ventilation and the length of stay in ICU were all positive (r =0.322,0.335,0.327,0.328,0.338,P =0.038,0.030,0.030,0.034,0.029).Conclusions The elevation of cTnI level may reflect the degree of myocardial damage in patients with sepsis cardiac failure,and it can be used as an indicator to predict the prognosis of the disease;the changes of many biochemical and clinical indexes suggest that the addition of Wushen decoction might elevate the clinical efficacy for treatment of patients with sepsis heart failure.

The effect of Succinate injection combined with Bifico on the myocardial enzymes changes of the children with rotavirus enteritis / 国际中医中药杂志

Objective To observe the effect of Succinate injection combined with Bifico on the myocardial enzymes changes of the children with rotavirus enteritis.Methods A total of 146 children with rotavirus enteritis were enrolled and included in this study. Children were randomly divided into the control group (n=73) and the observation group (n=73). The control group was received Bifico on the basis of routine treatment, and observation group was received Succinate injection combined with Bifico. The IL-17, IL-6, TNF-?, LDH, CK, and CKMB was detected by ELISA. The rates of clinical effects was compared.Results After treatment, the IL-17 (22.35 ± 4.21 ng/mlvs. 30.24 ± 6.07 ng/ml,t=2.395), IL-6(31.26 ± 6.14 ng/mlvs. 43.72 ± 8.22 ng/ml,t=2.347), TNF-? (35.62 ± 6.24 ng/mlvs. 49.18 ± 8.72 ng/ml,t=2.421), LDH (135.16 ± 31.25 U/Lvs. 174.08 ± 40.22 U/L,t=2.373), CK (37.82 ± 7.39 U/Lvs. 50.21 ± 11.16 U/L,t=2.385), and CKMB (90.14 ± 11.63 U/Lvs. 113.22 ± 18.35 U/L,t=2.392) in the observation group were lower than those in the control group (P<0.05). The rates of clinical effects was 94.5% (69/73) in the observation group and 83.6% (61/73) in the control group. There was significant difference between the two groups (χ2=2.352,P=0.047).Conclusions The Succinate injection combined with Bifico could reduce the inflammatory indices and alleviate the myocardial injury in the RVE patients.

Worry about ill consequences in cancer patients and its relationship with depression / 重庆医学

Objective To understand the worry situation about ill consequences in cancer patients and its relationship with depression.Methods The inpatients with cancer were extracted from 4 general hospitals of Wuhan and Beijing city by the cluster sampling.The self-designed questionnaires were adopted to survey the worry situation about ill consequences in cancer patients.The self-rating depression scale (SDS) was used to assess the patients' depression status.Results A total of 485 cancer patients were surveyed,including 204 males (42.1 ％),281 females(57.9 ％),and the mean age was (56.59 ± 11.19)years old.More than half of the patients usually or always worried about medical expenses.Worries about not taking care of their children,losing their lives,physical disability,leaving sequela and losing life ability also happened a lot.Patients worried more about losing their life,the possibility appearing depression was greater (P＜0.05).The younger the patients were,the greater the depression possibility was;the company staffs had lower risk of depression compared with those whose occupation was others (P＜0.05).Conclusion Cancer patients have different degrees of worries about ill consequences such as medical expenses,not taking care of their children and losing their lives and their worries about losing their lives could affect their depression status.

Worry about ill consequences in cancer patients and its relationship with depression / 重庆医学

Objective To understand the worry situation about ill consequences in cancer patients and its relationship with depression.Methods The inpatients with cancer were extracted from 4 general hospitals of Wuhan and Beijing city by the cluster sampling.The self-designed questionnaires were adopted to survey the worry situation about ill consequences in cancer patients.The self-rating depression scale (SDS) was used to assess the patients' depression status.Results A total of 485 cancer patients were surveyed,including 204 males (42.1 ％),281 females(57.9 ％),and the mean age was (56.59 ± 11.19)years old.More than half of the patients usually or always worried about medical expenses.Worries about not taking care of their children,losing their lives,physical disability,leaving sequela and losing life ability also happened a lot.Patients worried more about losing their life,the possibility appearing depression was greater (P＜0.05).The younger the patients were,the greater the depression possibility was;the company staffs had lower risk of depression compared with those whose occupation was others (P＜0.05).Conclusion Cancer patients have different degrees of worries about ill consequences such as medical expenses,not taking care of their children and losing their lives and their worries about losing their lives could affect their depression status.