RESUMO
Objective To investigate the relationship between serum soluble B7-H4(sB7-H4) expression and clinical pathological characteristics in patients with non small cell lung cancer(NSCLC),and its clinical significance.Methods 65 patients with NSCLC were selected as NSCLC group,58 patients with benign lung disease were selected as the benign lung disease group,another 45 healthy people of the same period in our hospital outpatient physical examination were selected as healthy control group.By enzyme-linked immunosorbent assay(ELISA) method,serum sB7-H4 and vascular endothelial growth factor(VEGF) were detected.The serum embryonic antigen(CEA) and cancer antigen-125(CA125) were detected by chemiluminescence method.The relationship between sB7-H4 and NSCLC and other pathological features,and the relationship of the tumor markers CEA,CA125,VEGF were analyzed.Results The level of serum sB7-H4 of the NSCLC group was (59.47±8.76)μg/L,which was significantly higher than (17.38±3.72)μg/L of the lung benign lesion group and (15.26±3.17)μg/L of the health control group,the differences were statistically significant(t=18.276,19.872,all P<0.01).The serum CEA,CA125,VEGF levels of the NSCLC group were higher than those of the lung benign lesion group and healthy control group,the differences were statistically significant(t=9.447,14.883,33.467;t=11.374,15.137,37.759,all P<0.01).The level of serum sB7-H4 of the NSCLC group after treatment was (35.47±7.46)μg/L,the difference was statistically significant compared with before treatment[(59.47±8.76)μg/L](t=4.372,P<0.01).The serum sB7-H4 level was correlated with NSCLC tissue differentiation degree,clinical stage,whether with lymph node metastasis (F=3.786,t=4.821,4.172,all P<0.01).In NSCLC patients,sB7-H4 level was positively correlated with serum CEA,CA125 and VEGF levels (r=0.643,0.727,0.586,all P<0.05).Conclusion The sB7-H4 may be involved in the occurrence and development of NSCLC,and it is expected to become a new target for NSCLC diagnosis and treatment.