Effect of aerobic training on physical fitness and cardiopulmonary resistance of university students / Efeito do treinamento aeróbico sobre a aptidão física e resistência cardiopulmonar dos estudantes universitários / Efecto del entrenamiento aeróbico sobre la aptitud física y la resistencia cardiopulmonar de estudiantes universitarios

ABSTRACT Introduction: The good performance of college students depends directly on their physical integrity, which is subordinated to good physical fitness and cardiopulmonary resistance. It is believed that aerobic training, an adaptation to the progressive increase of physical endurance, may benefit college students. Objective: Study whether aerobic training can affect college students' physical fitness and cardiopulmonary endurance. Methods: Through experimental comparison, the physical fitness and cardiopulmonary endurance of students in the aerobics elective class and the university athletics elective class were compared. Body indexes were measured before and after the intervention, statistically analyzed, and discussed according to the literature. Results: There were significant changes in the 50-meter run time for university students in the elective aerobics class from 9.24±1.71 to 7.81±2.02, the five-meter run from 11.56±1.03 to 7.87±0.23, the standing jump from 156.92±14.79 to 170.56±19.93, and the sitting flexion from 14.07±1.98 to 17.52±3.79. These changes accompanied the changes in cardiorespiratory endurance in the aerobics elective class. In contrast, the changes in student indicators in the track and field elective class were not as evident. Conclusion: Aerobic training positively impacted overall physical quality, including elevation of fitness indices and cardiopulmonary endurance in college students. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.

RESUMO Introdução: O bom desempenho dos estudantes universitários depende diretamente de sua integridade física, que está subordinada a uma boa aptidão física e resistência cardiopulmonar. Acredita-se que o treinamento aeróbico, uma adaptação ao aumento progressivo da resistência física, possa trazer benefícios aos estudantes universitários. Objetivo: Estudar se a prática do treinamento aeróbico pode afetar a aptidão física e a resistência cardiopulmonar dos estudantes universitários. Métodos: Através de comparação experimental, a aptidão física e a resistência cardiopulmonar dos alunos da classe optativa de aeróbica e da classe optativa de atletismo universitário foram comparadas. Os índices corporais foram mensurados antes e após a intervenção, trabalhados estatisticamente e discutidos conforme a literatura. Resultados: Houveram alterações significativas no tempo de corrida 50 metros pelos estudantes universitários da classe eletiva de aeróbica, de 9,24±1,71 para 7,81±2,02, a de cinco metros foi de 11,56±1,03 para 7,87±0,23, o salto em pé foi de 156,92±14,79 para 170,56±19,93, e a flexão em posição sentada de 14,07±1,98 para 17,52±3,79. Essas alterações acompanharam as mudanças de resistência cardiorrespiratória na classe eletiva de aeróbica, enquanto as mudanças dos indicadores em alunos na classe eletiva de atletismo não foram tão evidentes. Conclusão: O treinamento em aeróbico mostrou um impacto positivo sobre a qualidade física geral, incluindo elevação dos índices de aptidão física e da resistência cardiopulmonar nos estudantes universitários. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.

RESUMEN Introducción: El buen rendimiento de los estudiantes universitarios depende directamente de su integridad física, que está subordinada a una buena forma física y resistencia cardiopulmonar. Se cree que el entrenamiento aeróbico, una adaptación al aumento progresivo de la resistencia física, puede aportar beneficios a los estudiantes universitarios. Objetivo: Estudiar si la práctica del entrenamiento aeróbico puede afectar a la forma física y a la resistencia cardiopulmonar de los estudiantes universitarios. Métodos: Mediante comparación experimental, se compararon la forma física y la resistencia cardiopulmonar de los estudiantes de la clase optativa de aeróbic y de la clase optativa de atletismo universitario. Se midieron los índices corporales antes y después de la intervención, se trabajaron estadísticamente y se discutieron según la bibliografía. Resultados: Hubo cambios significativos en el tiempo de carrera de 50 metros de los estudiantes universitarios de la clase electiva de aeróbic, de 9,24±1,71 a 7,81±2,02, la carrera de cinco metros fue de 11,56±1,03 a 7,87±0,23, el salto de pie fue de 156,92±14,79 a 170,56±19,93, y la flexión en posición sentada de 14,07±1,98 a 17,52±3,79. Estos cambios acompañaron a los cambios de la resistencia cardiorrespiratoria en la clase optativa de aeróbic, mientras que los cambios de los indicadores en los alumnos de la clase optativa de atletismo no fueron tan evidentes. Conclusión: El entrenamiento aeróbico mostró un impacto positivo en la calidad física general, incluyendo la elevación de los índices de condición física y resistencia cardiopulmonar en estudiantes universitarios. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.

In vitro antiviral, antioxidant and in vivo antipyretic activity of three South Africa medicinal plants crude extracts / Actividad antiviral, antioxidante y antipirética in vivo de tres extractos crudos de plantas medicinales de Sudáfrica

This study investigated anti-viral, antioxidant activity and anti-pyretic of crude extract from Artemisia afra, Artemisia absinthium and Pittiosporum viridflorum leaves. The crude extracts were prepared by maceration using aqueous, methanol and dichloromethane respectively. Antiviral studies were evaluated with influenza virus using Fluorescence based - Neuraminidase inhibitors. Antioxidant activities determined with DPPH, Nitric oxide, hydroxyl and super oxide anion radicals' Anti-pyretic activities were evaluated using rats with yeast induced pyrexia. Total phenol, flavonoids, and pro-anthocyanin contents of the plants samples were evaluated using standard protocols. The crude extracts exhibited neuraminidase inhibitory activity against the influenza virus at different thresholds. Artemisia absinthiumaqueous extract showed the best activity against A/Sydney/5/97. Whereas Artemisia afra methanol crude extract displayed highest antioxidant potential against the tested antioxidant parameters. All the crude extracts significantly reversed yeast induced pyrexia in rats, similar to paracetamol. Thus, they could serve as natural remedy for respiratory diseases such as Influenza.

Este estudio investigó la actividad antiviral, antioxidante y antipirética del extracto crudo de hojas de Artemisia afra, Artemisia absinthium y Pittiosporum viridflorum. Los extractos crudos se prepararon mediante maceración utilizando metanol acuoso y diclorometano respectivamente. Los estudios antivirales se evaluaron con el virus de la influenza utilizando inhibidores de neuraminidasa basados en fluorescencia. Actividades antioxidantes determinadas con DPPH, radicales aniónicos de óxido nítrico, hidroxilo y superóxido. Las actividades antipiréticas se evaluaron utilizando ratas con pirexia inducida por levaduras. El contenido total de fenol, flavonoides y proantocianina de las muestras de plantas se evaluó utilizando protocolos estándar. Los extractos crudos mostraron actividad inhibidora de neuraminidasa contra el virus de la influenza en diferentes umbrales. El extracto acuoso de Artemisia absinthium mostró la mejor actividad contra A/Sydney/5/97. Mientras que el extracto crudo de Artemisia aframetanol mostró el mayor potencial antioxidante contra los parámetros antioxidantes probados. Todos los extractos crudos revirtieron significativamente la pirexia inducida por levaduras en ratas, similar al paracetamol. Por tanto, podrían servir como remedio natural para enfermedades respiratorias como la Influenza.

Comparison of Diagnosing and Staging Accuracy of PET (CT) and MIBG on Patients with Neuroblastoma: Systemic Review and Meta-analysis / 华中科技大学学报（医学）（英德文版）

To perform a systemic review and meta-analysis of the diagnostic accuracy of PET (CT) and metaiodobenzylguanidine (MIBG) for diagnosing neuroblastoma (NB),electronic databases were searched as well as relevant references and conference proceedings.The diagnostic accuracy of MIBG and PET (CT) was calculated for NB,primary NB,and relapse/metastasis of NB based on their sensitivity,specificity,and area under the summary receiver operating characteristic curve (AUSROC) in terms of per-lesion and per-patient data.A total of 40 eligible studies comprising 1134 patients with 939 NB lesions were considered for the meta-analysis.For the staging of NB,the per-lesion AUSROC value of MIBG was lower than that of PET (CT) [0.8064±0.0414 vs.0.9366±0.0166 (P＜0.05)].The per-patient AUSROC value of MIBG and PET (CT) for the diagnosis of NB was 0.8771±0.0230 and 0.6851±0.2111,respectively.The summary sensitivity for MIBG and PET (CT) was 0.79 and 0.89,respectively.The summary specificity for MIBG and PET (CT) was 0.84 and 0.71,respectively.PET (CT) showed higher per-lesion accuracy than MIBG and might be the preferred modality for the staging of NB.On the other hand,MIBG has a comparable diagnosing performance with PET (CT) in per-patient analysis but shows a better specificity.

school oral health education should focus on the consumption of sugars and cares should be put into the differences between urban and rural area. In addition, strengthening publicity of the sealant retention project,raising public awareness, and improving sealant retention quality are necessary to ensure the anti-caries effect / 口腔疾病防治

Objective@#To analyze the correlation between stage of oral disease and the transformation of children dental anxiety in first visit. @*Methods@#Children aged 45 to 74 months (13.7~6.2) years old with molar caries in the first visit were selected and divided into three groups: the acute stage group, the non-acute stage group, and the conventional examination group. The face version of the modified child dental anxiety scale (MCDASf) was used to evaluate the changes of anxiety before and after treatment. @*Results@#The data of correlation among 3 groups about dental anxiety showed a statistical difference (χ2 = 9.132, P = 0.010). Compared with acute stage group and non-acute stage group, a statistical significance in dental anxiety can be found (P<0.012 5). There was no correlation between anxiety prognosis and gender (P>0.05). @*Conclusion @#The occurrence and transformation of dental anxiety in children varied with different stage of oral disease. Dental anxiety can be improved significantly by appropriate therapy and behavior management.

Comparative study on the influence of two kinds of different self-locking brackets on the dental arch shape change in non-extraction patients / 口腔疾病防治

Objective@# By analyzing changes of dental arch width and length during the aligning and leveling period (non-extraction case) with two kinds of self-locking bracket, compare the difference between the active self-locking bracket with the passive bracket.@*Methods@#The data of dental arch perimeter change amount and dental arch width and length change amount (WU/L3, WU/L4, WU/L5, WU/L6, U/LL) were statistically analyzed using the correlation and regression method by comparing active and passive brackets for the correction of dental arch variations. Two different brackets for the correction of the measured values of the dental arch variations was analyzed by t-test. Results There were statistical relationships between the amount of arch perimeter increase and the amount of width and length increase. The regression equation was statistically significant (P < 0.05), It was greater impacted arch width increase to arch perimeter in the self-locking. The t-test results showed WU3, WL3, WL6, LR 4 measured values (P < 0.05) statistically significant in the active self-locking group and passive group. @*Results @#There were statistical relationships between the amount of arch perimeter increase and the amount of width and length increase. The regression equation was statistically significant (P < 0.05), It was greater impacted arch width increase to arch perimeter in the self-locking. The t-test results showed WU3, WL3, WL6, LR 4 measured values (P < 0.05) statistically significant in the active self-locking group and passive group. @*Conclusin @#Active and passive self-locking bracket have good arch expansion effecting. The active self-locking bracket is slightly dominant than the passive bracket in the expansion of the canine width whereas the active self-locking bracket is better than the passive in the expansion of the mandibular first molar and arch perimeter which should be widely applied to the appropriate cases.

DL0410, a candidate for anti-Alzheimer disease with multiple targets in multiple pathways / 中国药理学与毒理学杂志

OBJECTIVE To find a promising candidate for anti- Alzheimer disease (AD) with multiple targets in multiple pathways. METHODS A series of classifiers were constructed for predicting the active compounds against 51 key targets toward Alzheimer disease (AD) using the multitarget-quantitative structure- activity relationships (mt- QSAR) method. While drug screening assays were established to evaluate the predicted active molecules. In addition, various cellular models and animal models related with AD were set up to further study the effects of the active compounds. RESULTS A system for the discovery of Multitarget-Directed Ligands against AD was set up and applied, the predicted active compounds were validated by the drug screening assays, and several active compounds with multiple targets were discovered. Among them, DL0410 exerted high activity on H3R, α7nAChR, AChE and ERα, also displayed the most significant effect in improving the ability of memory and learning in several AD animal models. The study on its action mechanisms showed that it's effect may partially through increasing neurotransmitter, inhibiting oxidative emergency, inhibiting the expression of APP, and promoting long- term potentiation. Besides, DL0410 is of more safety than the first- line clinical medicines. CONCLUSION DL0410 is a promising candidate for further development for AD treatment.

Rituximab Followed by Mycophenolate Mofetil in Children With IgM Nephropathy.

IgM nephropathy presents with refractory nephrotic syndrome and its treatment is a significant challenge for pediatricians. We present two patients with IgM nephropathy and frequently relapsing nephrotic syndrome treated with rituximab and subsequently mycophenolate mofetil. Both showed complete remission, which 24 to 30 months later, was still maintained. The role of mycophenolate mofetil therapy in maintaining remission after successful treatment of rituximab in IgM nephropathy needs to be examined.

Elevated yield of Monacolin K in Monascus purpureus by fungal elicitor and mutagenesis of UV and LiCl

In China, Monascus spp., a traditional fungus used in fermentation, is used as a natural food additive. Monascus spp. can produce a secondary metabolite, monacolin K namely, which is proven to be a cholesterol-lowering and hypotensive agent. Hence, recently, many researchers have begun focusing on how to increase the production of monacolin K by Monascus purpureus. In the present study, we investigated the effect of the fungal elicitor and the mutagenesis of UV & LiCl on the amount of monacolin K produced by Monascus purpureus. The fugal elicitor, Sporobolomyces huaxiensis, was isolated from tea leaves and its filtrate was added into the culture filtrate of Monascus purpureus during growth to induct the production of monacolin K. The results showed that the highest amount of monacolin K produced by the liquid fermentation was 446.92 mg/mL, which was produced after the fungal elicitor was added to the culture filtrate of Monascus purpureus on the day 4; this amount was approximately 6 times greater than that of the control culture filtrate, whereas the highest amount of monacolin K produced by the mutated strain was 3 times greater than the control culture after the irradiation of UV light in the presence of 1.0 % LiCl in the medium.