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Objective To explore the impact of intermittent androgen deprivation therapy on prostate volume and lower urinary tract symptoms (LUTS) in patients with prostate cancer combined with prostatic hyperplasia (BPH),and to evaluate the clinical effect of intermittent androgen deprivation therapy as compared with conventional drug in patients with BPH.Methods Patients with prostate cancer (n=57) and BPH (n=83) were respectively treated with intermittent androgen deprivation therapy and finasteride combined with alpha-receptor antagonist.Prostate volume,international prostate symptom score (IPSS),quality of life index (QOL) and maximum urinary flow rate (Qmax) in patients were observed before and 1,3,6 and 12 months after treatment.Results The improvements in prostate volume,IPSS,QOL and Qmax were higher in prostate cancer patients treated with intermittent androgen deprivation therapy than in BPH patients treated with finasteride combined with alpha-receptor antagonist (P ＜ 0.05).Conclusions Intermittent androgen deprivation therapy can significantly reduce prostate volume and improve LUTS in patients with prostate cancer,and has a better clinical effect than finasteride combined with alpha-receptor antagonist treatment.
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The specific clinical characteristics have been observed in children with nephrotic syndrome combined wheezing diseases.However the link between nephrotic syndrome and wheezing disease was controversial.Evidences on the genetics,atopy,serum IgE level,Th1/Th2 disbalance,nitric oxide level,respiratory virus infection researches in nephrotic syndrome and wheezing diseases supported that nephrotic syndrome and wheezing diseases might have ,some relationship and have similar immune mechanism.
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OBJECTIVE:To describe the characteristics of children hospitalized for asthma and to identify the factors that may prevent re-hospitalization METHODS:162 children hospitalized for asthma were reviewed in respect to the personal history of asthma,medical care before admission,adequacy of the parent's knowledge on asthma,details of the current episode of asthma and the causes of hospital admission RESULTS:According to the pattern of symptoms in the previous 12 months,65 4% of the children had infrequent episodic asthma,26 5% frequent episodic asthma,and 8% persistent asthma Infrequent episodic asthma was much more common in the younger children(