Targeted surveillance and infection-related risk factors of nosocomial infection in patients after neurosurgical operation

The purpose of this study was to investigate the risk factors of nosocomial infection in patients after neurosurgical operations, so as to provide reasonable, effective preventative measures in the future. A total of 1,600 patients with brain tumors, hydrocephalus, craniocerebral trauma and vascular disease treated in the neurosurgery room were chosen for targeted surveillance; and through analysis on the clinical data of patients, the incidence of nosocomial infection, the site of infection and the distribution of pathogens, we investigated the infection-related risk factors. After operation, there were 128 cases with nosocomial infection, with the infection rate of 8.0%; among the several diseases, the postoperative infection rate of brain tumors was 28.13%, the postoperative infection rate of hydrocephalus was 21.88%, and the susceptible sitesin the first three places were lower respiratory tract, intracranial, urinary tract; a total of 69 pathogens were separated from 128 cases with nosocomial infection, and the first three pathogens were Acinetobacter baumannii, Klebsiella pneumoniae, Staphylococcus aureus, accounting for 21.74%, 17.39%, 11.59% respectively. The incidence of nosocomial infection was higher in patients with invasive operation during the procedure, with significant difference [P<0.05]. By targeted surveillance on the nosocomial infection in patients after neurosurgical operations, the nosocomial infection rate was high after neurosurgical operations. By strictly implementing the aseptic operation, it could reduce the invasive operation; effectively reduce the infection rate of patients, to facilitate the healing of patients and early rehabilitation

PREPARATION OF CHITOSAN FILM AND STUDY ON ITS HEMOSTATIC PROPERTIES / 解放军医学杂志

The aim of this study was to prepare chitosan film and to study its hemostatic properties. Chitosan film was prepared by casting the mixed solution of dialysed chitosan and gelatin after crosslinking with glutaraldehyde in a freeze dryer. Bleeding times were measured for bilateral back incisions (5 incisions on each side) in 4 New Zealand white rabbits. Using a randomized, blinded experimental design, one incision in each animal was treated with chitosan film, the other was treated with gauze. After bleeding stopped ,hemoglobin amount in films or gauzes was measured to determine the hemostatic effect. The results showed that the chitosan film adhered well to incisions. Bleeding times and hemoglobin amounts in chitosan film group were superior to those in gauze group( P