RESUMO
OBJECTIVE: To study the distribution of cancers among females with particular emphasis on cancer cervix in Kashmiri population, which is geographically and socio‑culturally distinct from the rest of India. MATERIALS AND METHODS: All patient records were screened from January 1, 2009 to December 31, 2011 at Regional Cancer Centre, Srinagar. Most common cancers among females were recorded and analysis of cancer cervix cases was performed. RESULTS: Female cancers comprised of 40% of total cancers with oesophageal and breast cancer as most common malignancies. Cancer cervix did not figure in top ten cancers and only 45 (0.01%) cases were recorded of the total of 3084 adult female cancers. CONCLUSION: We conclude that due to different socio‑cultural and sexual practices, this cancer is highly uncommon in Kashmir and screening or possibly should be directed specifically at only high risk selective subjects.
RESUMO
To compare the results of sequential with concurrent chemo radiotherapy in locally advanced squamous cell carcinoma of esophagus in terms of loco regional control, toxicity profile and overall survival,65 patients were enrolled between Jan 2008 and Dec. 2010, of which 37 were male and 28 female. Patients had histologically confirmed squamous cell carcinoma with locally advanced disease with no prior treatment in the form of chemotherapy, radiotherapy or surgery. Patients were divided into two groups and were comparable in terms of patient characteristics. In Group-I, 35 were given sequentially paclitaxel 175mg/ m2, cisplatin 75mg/m2 on day 1 of every 21 days for 3 cycles followed by external beam Radiotherapy followed by 3 more cycles of same chemotherapy. In Group-II, 30 patients were given two cycles of Induction chemotherapy same drugs and dosage as in Group-I and was followed by EBRT concurrent with paclitaxel 30mg/m2 given on day 1 of every week during radiation therapy treatment. The overall objective response rate at the end of treatment was superior 93.33% in Group-II as compared to 74.28% in Group-I. Thrombocytopenia was 73.33% and 17.14% in Group-II and Group-I respectively. Similarly, mucosites was higher 56.66% in Group-II as compared to 22.85% in Group-I. At 2 years of follow up, there was no statistically significant difference seen in overall and disease free survival.
RESUMO
AIM: To study the clinico-pathological aspects of lung cancer, and the outcome of various treatment modalities. METHODS: A retrospective review of histopathologically confirmed lung cancer patients who were registered and treated at our institution over a period of five years was carried out. RESULTS: A total of 321 patients were studied. There was a preponderance of males (91.9%) as compared to females (8.1%). Smoking history was present in 88% of the male patients. Cough was the main presenting feature in 71.6% of patients. Diagnosis was established by bronchoscopy in 94% of cases. Squamous cell carcinoma was observed in 77.3%, while 17.1% had small cell carcinoma. Radiotherapy formed the main treatment modality alone (22.4%) and in combination (27%). Out of the 321 patients, 206 were evaluable on follow-up. Local failure and distant metastasis were seen in 9.2% and 19.9% of cases, respectively. The overall survival rate of 2, 3 and 5 years was 19.9%, 13.59% and 6.79%, respectively. CONCLUSIONS:. The outcome of lung cancer is poor. Increased survival is possible if the disease is detected early, treated adequately with multi modality approach.