The release of sodium diclofenac from ointments formulated with various excipients

In vitro, the release of sodium diclofenac from different ointment bases at 1% concentration was studied. The rank order of the release pass dialysis membrane was as follow: Emugel carbopol 934, CMC, HPMC gel> emulsified ointment> absorption ointment> hydrophobic ointment.

Studying influences of some factors on ability of release and trandermal absorption of fluocinolone acetonid

The influence of different ointment bases and percutaneous penetration enhancers on in vitro release and anti-inflammatory efficacy of Fluoci-nolone acetonide was studied. The rank order of release through dialysis membrane was as follow: PEG> gel CMC> gel HPMC> gel carbopol> emugel>emultion. The anti-inflammatory efficacy of Fluocinolone acetonide on hairless rat skin was as follow: gel HPMC+0.5% I-menthol>gel carbopol +0.5% I-menthol > gel carbopol +0.5% I-methol > gel carbopol > oleaginous bases.

In vitro study on the influence of excipient on properties of ketoconazole in topical galenic forms

In vitro release and fungicidal effect of Ketoconazol from different ointment base at 2% concentration was studied. The rank order of the release pass cellophane membrane was as follow: Emulel > PEG ointments > emulsified ointment > carbopol 934, CMC, HPMC gel. The bank order of the fungicidal effect in vitro was as follow: emulgel and emulsified ointment > hydrophilic ointment

Study on the solid dispersion system of artemisinine

Enteric solid dispersions of artemisinine were prepared by spray drying using methacrylic acid copolymer (Eudragit L100) as carrier and hydroxypropylmethylcellulose (HPMC), Tween 20, PEG 6000, colloidal silica (aerosil) as additives. Spherical solid dispersion particles were obtained. Both solubility and dissolution rate of artemisinine studied in the medium pH 7.2 from all solid dispersions were markedly improved compared with that from the original or spray dried drug powder. The drug release rate of tablets that were made from the solid dispersion with drug-carrier ratio of 1:2 was nearly unchanged in medium pH 7.2 and was retarded in medium pH 1.5 in comparison with the solid dispersion powder.

The effect of the bases and added substances on the release and absorption of sodium diclofenac from its different ointment formulations

The effect of the bases and added substances on the release and absorption of sodium diclofenac from its different ointment formulations was studied. The results shown that the released extent of sodium diclofenac from different ointment bases across dialysis membrane was following the order: water soluble bases > emulsion bases > emugel bases > hydrocarbon bases and carbopol 934 gel with 1.2% I-menthol > carbopol 934 gel with 0.5% I-menthol > carbopol 934 gel with 3% oleic acid > carbopol 934 gel only. The percutaneous absorbed extent of sodium diclofenac across the rat hairless skin was evaluated indirectly based on antiinflammatory action on the rat leg stimulated edema by 0.1 ml of 1% caragenin solution. The average reduced percent of leg edema volume of the experimented rat group was obtained in such order: carbopol 934 gel with 1.2% I-menthol > carbopol 934 gel with 0.5% I-menthol > carbopol 934 gel with 3% oleic acid > carbopol 934 gel only. This result demonstrated that there was a correlation between in vitro release and in vivo percutaneous absorption of sodium diclofenac through the rat hairless skin.

Study on some factors influencing on the liberation of ketoprofene from ointment excipient

The in vitro release of Ketoprofen from different ointment bases at 2.5% concentration was studied. The rank order of the release pass dialysis membrane was as follow: emugel (used solid dispersion system with  - cyclodextrin) PEG ointments > carbopol 934, CMC, HPMC gel > emulsified ointment > absorption ointment > hydrophobic ointment