Recomendaciones para el uso de la hormona de crecimiento humana recombinante en pacientes pediátricos de talla baja en Colombia / Recommendations for treatment with recombinant human growth hormone in pediatric patients in Colombia

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Abstract In Colombia there are no guidelines for diagnosis and management of patients with short stature and for the use of recombinant human growth hormone, mainly caused by the diversity of training centers in pediatric endocrinology. In response to this situation, the Asociación Colegio Colombiana de Endocrinología Pediátrica leds the first colombian short stature expert committee in order to standardize the use of human recombinant growth hormone. This work had the participation and endorsement of a consortium of clinical experts representing the Sociedad Colombiana de Pediatría, Secretaría Distrital de Salud de Bogotá- Subred Integrada de Servicios de Salud Suroccidente, Fundación Universitaria Sanitas, Universidad de los Andes and some public and private health institutions in the country, in addition to the participation of methodological experts from the Instituto Global de Excelencia Clínica Keralty. By reviewing the literature and with the best available evidence, we proposed to unify definitions, a diagnostic algorithm, biochemical and dynamic tests with their reference parameters, a description of the considerations about growth hormone use among the indications approved by regulatory agency for medications and food in Colombia and finally a proposal for an informed consent and a medication fact sheet available for parents and patients.

Producción científica de los profesionales del Hospital Oncológico Docente Provincial "Conrado Benítez García" / Scientific production of professionals from "Conrado Benítez García" Teaching Provincial Oncological Hospital

Se efectuó un estudio descriptivo, retrospectivo y métrico en el Hospital Oncológico Docente Provincial "Conrado Benítez García" de Santiago de Cuba, en el periodo 1996-2013, para determinar la producción científica de sus profesionales tanto en revistas nacionales como extranjeras. En la serie fueron identificados 98 artículos científicos, el año de mayor cantidad de publicaciones fue el 2006 y la revista MEDISAN resultó la fuente con número superior de artículos; asimismo, los profesionales de esta institución publicaron más como coautores (62,8 %), sobre todo en la revista médica de su provincia (MEDISAN), con predominio de aquellos en la categoría académica de licenciado (34,7 %), los que ostentaban la categoría docente de auxiliar (24,5 %) y los acreditados con el grado científico académico de máster (47,1 % como autores principales y 14,3 % como coautores). Cabe señalar que el sexo femenino sobresalió como el de mayor aporte de publicaciones científicas.

A descriptive, retrospective and metric study was carried out in "Conrado Benítez García" Teaching Provincial Oncological Hospital in Santiago de Cuba, in the period 1996-2013, to determine the scientific production of its professionals either in national as foreign journals. In the series 98 scientific works were identified, the year of higher quantity of publications was 2006 and journal MEDISAN was the source with higher number of works; also, the professionals of this institution published more as co-authors (62,8%), mainly in the medical journal of their province (MEDISAN), with prevalence of those in the licentiate academic category (34,7%), those with the teaching category of assistant professor (24,5%) and those credited with the academic scientific degree of master (47,1% as main authors and 14,3% as co-authors). It is necessary to point out that the female sex was that of higher contribution to scientific publications.

Voluntary modulations of attention in a semantic auditory-visual matching Task: an ERP study

The present study explores the neural correlates of voluntary modulations of attention in an auditory-visual matching task. Visual stimuli (a female or a male face) were preceded in close temporal proximity by auditory stimuli consisting of the Spanish word for "man" and "woman" ("hombre" or "mujer"). In 80 percent of the trials the gender of the two stimuli coincided. Participants were asked to mentally count the specific instances in which a female face appeared after hearing the word "man" (10 percent of the trials). Our results show attention-related amplitude modulation of the early visual ERP components NI and anterior P2, but also amplitude modulations of (i) the N270 potential usually associated with conflict detection, (ii) a P300 wave related to infrequency, and (iii) an N400 potential related to semantic incongruence. The elicitation of these latter components varied according to task manipulations, evidencing the role of voluntary allocation of attention in fine-tuning cognitive processing, which includes basic processes like detection of infrequency or semantic incongruity often considered to be volition-independent.

Methodological considerations related to sleep paradigm using event related potentials

In the last few decades, several works on event related potentials (ERPs hereafter) during sleep have been reported. In spite of numerous studies, clear methodological rules for this kind of study are often missing, making it difficult to valorize the scope of these results. We propose here a description of methodological aspects to be considered when evaluating ERPs during sleep. The use of Rechtschaffen and Kales rules versus automatic methods is assessed, plus the additional use of certain quantitative measures. Additionally, two topics are discussed which must be controlled in ERPs sleep studies: the First Night Effect, and sleep disturbances. Better control of experimental paradigms is relevant for the growth of the neuroscience of sleep.

Síndrome de déficit atencional e hiperactividad (SDAH): ¿exclusividad de los niños ? / Attention-deficit hyperactivity disorder syndrome (ADHD)

El síndrome de déficit atencional es uno de los problemas frecuentes en neuropsiquiatría. Es interesante para los pediatras conocer la evolución de los pacientes a futuro, es decir, cómo se desarrollan y desempeñan en la vida adulta los niños que han padecido este problema. En este artículo se realiza una revisión del déficit atencional del adulto.

Effect of Psychostimulants on Distinct Attentional Parameters in Attentional Deficit/Hyperactivity Disorder

Although there is extensive literature about the effects of stimulants on sustained attention tasks in attentional deficit/hyperactivity disorder (ADHD), little is known about the effect of these drugs on other attentional tasks involving different neural systems. In this study we measured the effect of stimulants on ADHD children, both in the electroencephalographic (EEG) activity during sustained attentional tasks and in psychometric performance during selective attentional tasks. These tasks are known to rely on different cortical networks. Our results in children medicated with 10 mg of d-amphetamine administered 60 min before the study indicate (i) a significant increase in amplitude but not latency of the P300 component of the event-related potential (ERP) during the sustained attentional task and (ii) a significant improvement in the reaction times and correct responses in the selective attentional task. In addition to supporting the use of stimulants in children with attentional deficit/hyperactivity disorder, these results show a multifocal activity improvement of cortical structures linked to dopamine, and interestingly, to attention. All these analyses are framed in a wider study of diverse attentional functions in this syndrome.