Gene-gene interaction of GJB2, SOD2, and CAT on occupational noise-induced hearing loss in Chinese Han population / 生物医学与环境科学（英文）

The effects of genetic factors on the noise-induced hearing loss (NIHL) are still unclear. In the present study, eight single-nucleotide polymorphisms (SNPs) included rs1227049 and rs3802711 (CDH23), rs1695 (GSTP1), rs137852540 (GJB2), rs2289274 (PMCA2), rs4880 (SOD2), rs7943316, and rs769214 within CAT that might associated with NIHL were further validated in Chinese workers. The results showed that the carriers of the T allele (AT+TT) of rs7943316 and A allele (GA+AA) of rs769214, were significantly associated with an increased risk of NIHL compared to those with AA genotype (P<0.05) and GG genotype (P<0.05). Moreover, a significant three-locus model (P=0.0107) involving rs2016520, rs9794, and rs1805192 were observed that might associated with NIHL, with 53.95% of testing accuracy. Thus, our present study provided the evidence that GJB2, SOD2, and CAT genes might account for the NIHL development in independently and/or in an interactive manner.

Roles of peroxisome proliferator-activated receptors polymorphisms, haplotypes, levels on C-reactive protein and their interactions with abnormal body weight / 中华流行病学杂志

Objective To explore the roles of peroxisome proliferator-activated receptors (PPARs) on the levels of serum C-reactive protein (CRP) and the interactions of PPARs haplotypes with abnormal body weight.Methods Subjects (n=644) were randomly selected from the cohort ‘Prevention of Multiple metabolic disorders and Metabolic syndrome in Jiangsu province (PMMJS)'Variance test,t test and lineal regression were used to analyze the associations between PPARs polymorphisms and the levels of CRP.The association between PPARs haplotypes and serum CRP levels as well as the interaction of PPARs haplotypes with abnormal body weight were analyzed,under the SNPStats software.Results After adjusting for sex,age,blood pressure,cigarette smoking,alcohol drinking and so on,data showed that both rs1800206 and rs9794 were associated with the changes along with the levels of CRP (P＜0.05).After adjusting for the same factors,haplotypes of AVG and CVG in PPARα,CG in PPARδ appeared to be associated with the increase (P＜0.05) while haplotypes of CC in PPARδ,CPCAC in PPARγ were associated with the decrease of CRP levels (P＜0.05).Results from the Interaction analysis also noted that the interactions did exist between abnormal body weight and both AVG,CVG in PPARαt,and CG in PPARδ.Conclusion PPARs polymorphisms and haplotypes were associated with CRP.Interaction between PPAR α/δand abnormal body weight might contribute to the levels of CRP.