RESUMO
Objective To investigate the histopathologic changes of andometrium and research the cause of abnomal uterine bleeding in permenopausal women.Methods The biopsy sample of andometrium of 870 cases with abnomal uterine bleeding in permenopausal women were restrospectively analyzed.Results The most commonly hostopathologic change in andometrium of abnomal ulterine bleeding in permenopausal women is endometrial hyperplasia(76.67%).The most cases were simple hyperplasia(66.12%).3.0%of cases were endometrial carcinoma,most of them were well-differentiated endometrioid adenocarcinoma(88.46%).The morphological features of the endometrial adenocarcinomas is loss of polarity of the endometrial glands.The tumor cells have large round vesicular nuclei,prominent nucleoli and coarse chromatin.In addition,endometrial stroma was instead of by the fibrous and/or granulation tissue type stroma,usually with inflammatory response.Conclusions Abnormal ulterine bleeding occurred mainly in permenopausal period.Endometrial hyperplasia is the main cause of abnomal ulterine bleeding in permenopausal period.Most endometrial carcinomas in perimenpausal period are well-differentiated endometrioid adenocarcinomas.An important differential diagnosis of the endometrioid carcinoma in a curettage specimen is to differentiate it from atypical endometrial hyperplasia and atypical polypoid adenomyoma.