Preparation and Physicochemical Characterisation of Suryaprabha Gulika

Suryaprabha gulika is a Kharaleeya preparation mentioned in the Gulika prakarana of Sahasrayogam indicated for Sula, Swasa, Kasa and Mahajwara. It contains eleven ingredients namely Suddha Parada, Suddha Gandhaka, Suddha Hingu, Amalaki, Harithaki, Vibheethaki, Sunti, Pippali, Maricha, Yavani and Suddha Vatsanabha triturated for 6 hours in Jambeera swarasa. In this paper, the work done on pharmaceutical and analytical aspects of Suryaprabha gulika is detailed. Pharmaceutical study included Sodhana of Parada, Sodhana of Gandhaka, preparation of Kajjali, Sodhana of Hingu, Sodhana of Vatsanabha and the preparation of final product whereas the analytical study included evaluation of organoleptic characters, physico chemical parameters and analysis based on modern instrumentation techniques such as X-ray Fluorescence (XRF), X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM) and particle size analysis.

Ultrasound /Computed tomography Guided Fine Needle Aspiration Cytology of Abdominal Lesions

Background:Abdominal masses always are mystery in clinical prac?ce. Improvements have taken place in fine needle aspira?on cytology with technical advances in imaging methods of ultrasound and CT. Aims:To study the u?lity of guided FNAC in the diagnosis of abdominal lesions and categories the abdominal lesions. To study cytological features of abdominal lesions and correlate with histopathological features wherever possible. Materials and methods: The study included 82 abdominal lesions. History, clinical features, radiological inves?ga?ons were obtained in each case. USG or CT guidance was used and the FNA procedure was done. Smears were stained with Giemsa and viewed under the microscope for diagnosis. Diagnos?c yield was 95%. Extra material obtained was given for cell block. Results: The age was from 14 years old to 82 years and majority of them were in the age group of 40 – 60 years. Male to female ra?o is 1:1.1. Among 82 cases, 45 cases (54.87%) were malignant, followed by 17 cases (20.74%) benign, 14 cases (17.08%) inflammatory, 04 cases (4.87%) suspicious of malignancy and 02 cases (2.44%) unsa?sfactory for evalua?on. Majority of the cases are in liver and hepatocellular carcinoma was the most common malignant lesion. In 60 cases histopathological correla?on was available and for these cases the diagnos?c accuracy is 95%, sensi?vity is 92.1%, specificity is 100% and p value is <0.001 which is highly significant. Conclusion:Abdominal fine needle aspira?on cytology is simple, cost effec?ve, rapid and repeatable procedure which helps in categorizing the abdominal lesions.

Prevalence of anatomical variations of the position of appendix in acute appendicitis by ct scan

Background: The present study aims to find out age and gender prevalence of different anatomical positions ofappendix in acute appendicitis in a tertiary care hospital in chennai. Appendix may be placed in differentpositions, but the base of appendix is connected to the cecum. Based on the variations in the positions, appendixis classified into six types: retrocecal, pelvic, subcecal, paraileal, retroileal and subhepatic.Materials and methods: This study was done over a period of 1 year from June 2018 to June 2019 in 75 patients.Anatomical location of appendix was studied in acute appendicitis in different age groups and gender populations.Result: This study was conducted on 75 cases consisting of 40 (53%) males and 35(47%) females. Males weremore in number than females. Clinically diagnosed acute appendicitis cases were subjected to CT abdomen.Anatomical locations of the appendix were as follows: Retrocecal position was most commonly seen in 32individuals (43%), Pelvic in 25 individuals (33%), Subcecal in 10 individuals (13%), Postileal in 6 individuals(8%) and preileal in 2 individuals (3%). The incidence was more common in the age group of 31 to 40 years(33%).Conclusion: Retrocecal position is the most common location in our patients. CT is a good diagnostic indicatorfor acute appendicitis. As appendix is the most variable organ in the abdomen these findings are helpful forsurgeon to operate during appendicitis.

Chemistry Of Kupipakva Rasayana W.s.r. To Tamra Sindoora

Kupipakva rasayana are unique pharmaceutical procedure in the field of Rasashastra where in Mercury along with other minerals and metals are sublimated by subjecting it to gradual increase in temperature for specific time. They are more potent and quick acting even in smaller dose. Tamra Sindoora is one such Kupipakva Rasayan which is not that much popular and widely used in daily practice. But it is having a wide range of therapeutic utility. It is a combination of Parada (mercury), Gandhaka (sulphur) and Tamra (copper) in the ratio of 1:1:1/2. Chemistry itself includes the determination of chemical and biological incompatibilities among the various ingredients of a prescription. Here we will come to know about various synthetic methods by which natural substances are converted into products with more favourable therapeutic or pharmaceutical properties. In the present paper will discuss about probable chemistry of Tamra Sindoora.

Behavioural Determinants for Obesity: A Cross-sectional Study Among Urban Adolescents in India / 예방의학회지

OBJECTIVES: To measure the prevalence of behavioural risk factors for obesity among urban adolescent school children in Chennai, India. METHODS: This study was performed as a cross-sectional study using a World Health Organization-designed Global School-based Student Health Survey questionnaire (modified for India) among adolescent school children studying in 30 randomly selected secondary and higher secondary schools in Chennai city. 1842 adolescents studying in the VIII to XII standards were randomly selected for the study. RESULTS: In the present study, 40.7% of the students ate fruit one or more times per day and 74.5% of the students ate vegetables one or more times per day. Nearly 20% of the students ate fast food items on 4 to 7 days during the previous week. Among the students, 30.4% watched television for more than two hours per day. Nearly 68% of the girls and 22% of the boys did not participate in outdoor sports activities. When the pattern of physical activity of the students was assessed, it was observed that 15.6% were inactive, 43.4% were minimally active, and the remaining 41.0% belonged to the category of health enhancing physical activity. Among the students, 6.2% were overweight and 5.2% were obese. CONCLUSIONS: The prevalence of risk factors for obesity was quite high among the adolescents. This study also showed that a great proportion of overweight/obese adolescents had a correct perception of their body weight and they were making efforts to modify risk factors such as television viewing, computer use, a sedentary lifestyle, and unhealthy dietary habits.

Serum albumin in poorly differentiated, oral squamous cell carcinoma: a possible diagnostic marker of significance / Albumina sérica em carcinomas de células orais escamosas e pobremente diferenciadas: um possível marcador de diagnóstico de significância

Objectives: Serum albumin is considered to be the most potent and abundant extra-cellular anti-oxidant thatmight have a protective role in the ongoing process of transition of the various oral pre-cancerous lesions andconditions into frank malignant degenerations. The aim of this study was to check the reliability of serum albuminas one of the diagnostic anti-oxidant parameter. Materials and methods: The study consisted of seraanalysis of albumin in the age and sex matched normal healthy adults and patients with histologically proven,poorly differentiated oral squamous cell carcinoma. The results were analyzed using Student’s t-test andwere averaged as mean ± standard deviation. In above test, p-values less than 0.05 were taken to be statisticallysignificant. The normality of data was checked before the statistical analysis was performed. Results:The study revealed variations in sera levels of albumin to be statistically significant with the mean level ofsera albumin to be 4.956 ± 1.0579 in controls as against 3.6933 ± 1.2177 in patients with histologically proven,poorly differentiated, oral squamous cell carcinoma. Conclusions: The results of the study emphasize theneed for more studies with larger sample sizes to be conducted before a conclusive role could be drawn infavor of sera levels of albumin as diagnostic markers of significance in oral squamous cell carcinoma.

Objetivos: A albumina sérica é considerada o antioxidante extracelular mais poderoso e mais abundante, que pode exercer um papel protetor no processo de transição das várias lesões e circunstâncias pré-cancerígenasorais em degenerações malignas. O objetivo deste estudo foi verificar a confiabilidade da albumina sérica como um dos parâmetros de diagnóstico antioxidante. Materiais e métodos: A análise consistiu no estudo da albumina sérica em pacientes adultos saudáveis normais, separados por idade e sexo, e em pacientes com carcinoma oral de células escamosas pobremente diferenciadas com evidência histológica comprovada. Os resultados foram analisados usando o teste t de Student, e as médias foram calculadas com ± desvio-padrão. No teste citado, os valores de p menores que 0,05 foram considerados estatisticamente significantes. A normalidade dos dados foi verificada antes da realização da análise estatística. Resultados: O estudo revelou diferenças estatisticamente significantes nos níveis de albumina sérica com o nível médio de 4.956 ± 1.0579 nos controle sem contraste com 3.6933 ± 1.2177 nos pacientes com carcinoma oral de células escamosas pobremente diferenciadas.Conclusões: Os resultados do estudo enfatizaram a necessidade de mais estudos com tamanhos de amostra maiores antes que um papel conclusivo possa ser atribuído, em favor dos níveis de albumina sérica,como marcador diagnóstico para o carcinoma oral de células escamosas.