RESUMO
The side effects of anti-nociception chemical drugs caused notice to medical plants. This study was performed to investigate the effects of hydroalcoholic extract of Thymus vulgaris [TV] on neurogenic and inflammatory pain in formalin test in mice. 40 male albino mice [20-30 gr] were used. TV [100, 500 mg/kg] as extract and saline were injected 30 mine before formalin test. Indexes for evaluation were duration of licking and foot elevation for assessment of acute pain [5 min] and chronic pain [15-40 min] after injection of formalin 5% [25 microl] in paw. Results indicated that TV has analgesic effect in both doses [P<0.01], and higher dose [500 mg] was more effective. Findings showed that hydroalcoholic extract of TV can modulate acute and chronic pain. Further research is required to determine the mechanisms by which TV has an inhibitory effect on pain sensation
RESUMO
Since uses of antinoceception chemical drugs for relief of pain have many side effects; today medical plants are very noticeable. The present work investigated the effects of Hydroalcoholic extract of Thymus vulgaris [TV] on acute pain in Hot plate and Tail flick models. Albino mice [20-30 gr] were used for this study. Hydroalcoholic extract of TV seed was injected in doses of 100 and 500 mg/kg 30 min before test. Then the analgesic effect of the drug on acute pain was evaluated using Hot plate and Tail flick models. Results indicated that TV has analgesic effect in both doses in both models [P<0.01], and higher dose of the drug was more effective. These findings showed that TV could modulate acute pain. Further research is required to determine the mechanisms by which TV has an inhibitory effect on pain sensation