Chemical composition of the essential oil from aerial parts of Echinophora platyloba DC. from Iran

Essential oils and various extracts from plant are of great interests in the industry and scientific research. This study was designed to examine the chemical composition of essential oil and of Echinophora platyloba from Iran. The chemical composition of the hydrodistilled essential oil of the air-dried aerial parts of Echinophora platyloba growing wild in Iran was obtained by hydrodistillation and was analyzed by gas chromatography [GC] and gas chromatography-mass spectrometry [GC-MS]. The species is poor in essential oil [yield=0.7%]. Twenty-nine constituents representing 97.43% of total oil have been identified. The main constituents of the oil were found to be [Z]-beta-ocimene [26.71%], delta-3-carene [16.16%], Limonene [6.59%]. Other representative compounds were identified as Cis-3-hexylbenzoate [4.57%], Spathunenol [4.57%], Myristicin [4.48%], Myrcene [4.31%], 4-decanolide [4.2%] and alpha-Pinene [4.03%]. The oil of Echinophora platyloba consists of 16 monoterpenoids [69.55%] and 5 sesquiterpenoids [7.08%]

[Evaluation of the relationship between ovarian dysgermlnomas and the results of DNA analysis]

This paper studies the relationship of DNA analysis ploidy and stage of ovarian dysgerminoma and its prognosis with flowcytometric evaluation. The files and specimens from 24 cases [mean age 18/2+/-4/5 years] seen at Mirza Kouchak khan and Imam Khomeini hospitals between 1992 and 1997 were assessed and the patients followed for period of five years. There were 11 cases [45/8%] in stage I, 2 [8.3%] in stage II, 7 [29.2%] in stage III and 4 [16.7%] in stage IV. DNA aneuploidy was revealed in 13[54.2%] of tumors. There were 6 [15%] deaths, 7 [29.2%] recurrences and 11 [45.8%] free from the disease during the follow-up. DNA ploidy was significantly related to prognosis [p = 0.0006] and stage [x[2] = 15.9, p = 0.04]. The deaths and recurrences in cases with DNA aneuploidy were 30.5% and 53.8% respectively; only 7.7% were free. The most frequent aneuploidy was in stage III and IV [85/7% and 75% respectively]. Within microscopic data, mitosis, pleomorphism, necrosis and hemorrhage significantly related to DNA ploidy [p< 0.05]. The frequency of aneuploidy was greater in mitosis > 8 in HPF, higher pleomorphism and presence of necrosis and hemorrage. Our study revealed that DNA aneuploidy in ovarian dysgerminoma is related to higher staging and poor prognosis