RESUMO
Introduction: Stroke is a common cause of mortality and morbidity in developing countries; stroke is second leading cause of death after cardiac disease worldwide. Apart from established major risk factors for Ischemic Stroke [IS] i.e.; Hypertension, Diabetes Mellitus, Smoking and Hyperlipidemia, a burning but still debatable issue is raised serum C - reactive protein [CRP], that is also thought to be the major risk factor for acute IS due to participation in formation of Atherosclerosis in the cerebral vessels in genetically prone patients
Objective of study: To find out significance of serum levels of CRP among CT scan proved acute ischemic stroke patients
Study Design and Place: This is a prospective observational study was conducted at Department of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro/Hyderabad from July 2009 to June 2010
Data Collection: Patients meeting the inclusion criteria were enrolled in this study after obtaining informed consent, and were evaluated thoroughly for c reactive protein and other risk factors. All the selected cases were investigated for; Complete blood count, Urine detail report, CT scan brain plain, Serum C-Reactive Protein [CRP] Level, Fasting and Random Blood Sugar, Fasting Lipid Profile ECG and X-Ray chest PA View. The data was collected on a predesigned proforma designed for this study
Results: Out of 150 selected adult cases of CT scan proved Ischemic Stroke, male were 120 [80 %] and female were 30 [20 %]. Male to female ratio was 4:1. Their ages were between 20-80 years. Among these patients high level of CRP [> 10mg / L] was found in 132 [88 %]. Out of these Male were 110 [73.3 %] and that of Female were 22 [14.7%] respectively. Frequency of other major risk factors in male and female IS patients was also observed
Conclusion: A close relationship between high level of CRP and acute IS was found, because in acute IS patients high levels of CRP was observed but again it needs further studies high sample size to establish the c reactive protein as a independent risk factor for acute ischemic stroke
RESUMO
Objective: To find out the frequency of helicobacter pylori antibodies [IgG] among cases of ischemic stroke
Study Design: Cross-sectional study
Place and Duration: Medical Unit-II, Liaquat University Hospital Jamshoro/Hyderabad, from July 2009 to June 2010
Methodology:Helicobacter pylori [H.pylori] antibodies [IgG] on ELISA and color doppler ultrasound of carotid arteries were performed in CT Scan confirmed cases of ischemic stroke along with other routine investigations. A pre-designed proforma was used to record the data
Results: Among 150 CT scan confirmed ischemic stroke cases, 110 [73.3%] were males and 40 [26.7%] were females [2.7:1]. The H.pylori antibodies [IgG] were present in 121 [80.7%] cases among which males were 99 [66%] and females were [14.7%]
Conclusion: H.pylori antibodies [IgG] were present in very high proportion [80.7%] among cases of ischemic stroke