[ effect of cabergoline on level of liver enzymes and serum proteins in adult male rat]

The liver has an important role in the metabolism of chemical drugs and plasma protein synthesis. Caberoline is used in the treatment of hyperprolactinemia and Parkinson disease and some of other disorders. This study aimed to find the effect of cabergoline on the liver enzymes and serum proteins. In this experimental study 40 adult male Wistar rats were divided in to five equal groups. The drug was subcutaneously injected for 14 days. The experimental groups received 0.1, 0.5 and 1 mg/kg respectively. The control group had no drug and the last group received distilled water. At the end, blood samples were taken from all subjects and liver enzymes, ALT [Alanine Transaminase], AST [Asportate Transaminase], ALP [Alkaline phosphatase], Albumin and total protein were determined by outoanalyzer in order to evaluate the liver function. The results were analyzed by non-parametric [K Independent Sample] tests. No significant differences were observed in the level of ALT and AST enzymes between cases and control groups. The level of ALP in case groups [474 +/- 53.06, 471 +/- 28.7] showed a significant decrease compared to the control group [551 +/- 31.64]. Total protein showed a significant decrease in the groups who received medium and maximum doses of cabergoline [4.6 +/- 0.05 and 4.46 +/- 0.02 compared to 4.71 +/- 0.08 in control group]. As there was no significant difference in the level of AST and ALT as the main indicators of liver function, it could be concluded that cabergoline as a dopamine antagonist has no side effects on the liver parenchymal cells, but more study seems to be needed

Effect of trigonella foenum - graecum L. seed extract on concentration of testosterone and spermatogenesis in rats

Overpopulation is a global problem with grave implication for the future. There is evidence of broad increase of plants accessible and useful which potentially could be anti-fertility and regulate the reproduction in males. Despite the vast use of Trigonella foenum-graecum in daily lives, our knowledge of its effect on testicular function is very limited. So, the need for a careful study of potential have been found in order to minimize the problem. In the present study T. foenum-graecum is warranted. The present study aims at investigating the effect of T. foenum-graecum seed extract on concentration of testosterone and spermataogenesis in rat. The implication of this study could be helpful for family planning and fertility. Fifty rats were divided into five groups including control, sham and experimental groups. Each of the rats in experimental group was treated orally with 50, 100 and 150 /mg dose of T. foenum-graecum extract for fourteen days. The sham group received distilled water and the rats without administered T. foenum-graecum extract or distilled water were considered as control group. After fourteen days, the blood sample from each rat was collected and concentrations of FSH, LH and testosterone hormones were measured. Furthermore, the sample tissue of testis and epididymis from each rate were collected and histological study was carried out to achieve maximum information concerning the change of the testis and epididymis tissue between experimental and control groups. The results obtained from this study were statisticlly analysed using ANOVA and Tukey test. The result of the study indicated that the concentrations of LH and testosterone in experimental groups relatively reduced in comparison with control group [p