RESUMO
Association between celiac disease [CD] and type I diabetes mellitus [DM] has been evaluated in different studies. If CD coexists with DM and is not diagnosed, it can lead to errors in diagnosis and management. The aim of this study is to evaluate the prevalence of celiac disease in patients with type I DM. So that with timely diagnosis and treatment of CD in DM patients, the progress of the disease and its complications are prevented. The study was done on 250 patients [M=102 and F=148] with type I DM and mean age of 18.7+/-9.9 years. Total IgA of serum was measured in all of the patients and anti-endomysial antibody [AEA] was measured in those patients who had a normal range of IgA. Then endoscopy and biopsy of duodenum was done for AEA-Positive patients and pathologic evaluation was done according to Marsh's classification. Total IgA of serum in all of the patients was in normal range and 6 patients [2.4%] were AEA-positive in whom duodenal biopsy was done. Histological changes of samples according to Marsh's classification were grade I in 2, grade II in 3 and grade IIIb in one patient. Out of patients with CD, 3 patients according to hematologic and biochemical tests had Iron deficiency anemia that 2 of them also had abdominal symptoms. Three of them were without any symptoms. Information obtained from this study expresses a high prevalence of CD in patients with type I DM [2.4%] relative to general population [0.6%]. Fifty percent of patients with CD had no signs or symptoms. Thus evaluation of patients with type I DM regardless of symptoms is recommended for CD
RESUMO
The presence of human T-cell leukemia virus [HTLV-I] carriers in Fars province, southern Iran, was investigated. The sera of 160 randomly selected thalassemia patients, a well - known high-risk group for transfusion-associated viral infections, were screened for detection of antibodies to HTLV-I by the enzyme-linked immunosorbent assay method [ELISA], positive results were confirmed by Western blot [WB] analysis. Patients were ages 6 to 24 years, from Shiraz and nearby cities. Four patients were found to be seropositive