AgNOR stain in normal, cirrhotic and carcinomatous liver

In this era of tumor marker AgNOR stain has still retained the diagnostic yield in tumor pathology. This study was conducted to evaluate the role of AgNOR number and morphological features in cirrhotic and carcinomatous liver. A total of one hundred liver biopsy specimens were included, twenty cases were of hepatocellular carcinoma, sixty were those of cirrh0sis of the liver and twenty cases with normal histology as control. The mean AgNOR count, size and distribution were significantly of higher grade in hepatocellular carcinoma as compared to cirrhosis of liver

FNAC and core needle biopsy - A comparison in space occupying lesions of liver

A prospective analysis was conducted on 110 FNAC and results were compared with histologicul reports of patients with intrahepatic focal defects. Cytology permitted a diagnosis of the lesion in 98% cases. When aspirates with insufficient material were excluded [4], the diagnostic accuracy of FNA was 94%. Among the 106 patients who underwent both procedures, FNAC and CNB had the some diagnostic accuracy 94% i.e., sensitivity 96% and specificity 93% of FNAC. There were no complications during the execution of FNAC and CNB. FNAC is an effective and safe method in the diagnosis of focal hepatic lesions, with diagnostic accuracy almost similar to that of CNB. When the two techniques are combined, the accuracy of the diagnosis of malignancy of focal liver lesions increases