[Association between serum leptin and adiponectin and bone mineral density in 40-60-year-Old postmenopausal women]

Osteoporosis is the most common metabolic bone disease, which leads to a decrease in bone mass and disorders in its structure. Leptin and adiponectin are hormones secreted from the adipose tissue. The objective of this study was to determine association between serum leptin and adiponectin and bone mineral density in postmenopausal women 40-60 years old. This cross-sectional study included was 85 postmenopausal women, 40-60 years old. Samples of fasting blood were taken from the women in order to determine the serum concentrations of leptin and adiponectin, and bone mass density [BMD] was measured by the DXA method in two areas, i.e., L2-4 and the femoral neck. 4.5 kg/m2, respectively. There was a significant inverse relationship between +/- 5.4 years and +/- 29.4. The means +/- SD of age and body mass index [BMI] of the subjects were 52.4 the serum leptin level and BMD in the L2-4 area [p=0.02]. The data also showed a negative association between the serum adiponectin level on the one hand, and the BMD of the femur [p=0.03] and the bone mineral content [BMC] of the vertebral column [p=0.03] on the other. Leptin and adiponectin have inverse associations with the bone mineral density

[Assessment of relationship between serum leptin and adiponectin and bone mass with energy intake and nutrients in postmenopause women of 40-60 years old]

Adequate nutrition is crucial for growth and maintenance of the body skeleton health. Nutrients consumed affect leptin and adiponectin levels and bone mass. This study was done to determine the relationship between serum leptin, adiponectin and bone mass with energy intake and nutrients in postmenopausal women, 40-60 years old. The present cross-sectional study was done on 85 postmenopausal women, aged 40-60 years. Samples of fasting blood were taken to determine concentrations of leptin and adiponectin of serum and bone mineral density was measured by the DXA method in the two areas of L2-4 and the femoral neck. Food intake was documented using questionnaires including frequency of food and was analyzed by FP2 Software. Leptin had a negative relationship with energy intake, protein and magnesium and a positive relationship with carbohydrate; there was a positive relationship between adiponectin and energy and carbohydrate. BMD of femur had a negative relationship with energy and carbohydrate, while it had positive relationship with calcium, and there was direct and significant relationship between BMD of the spine and zinc. Increase in consumption of carbohydrate and decrease in consumption of protein lead to increase in leptin. Consumption of calcium and zinc can have a protective effect on bones