Lack of hypotensive effect of pindolol in dogs under enflurane anesthesia

Intravenous administrations of beta blockers are indicated in the prevention and treatment of disturbances of the cardiovascular system by anaesthesia especially against the effect of exaggerated sympathetic activity. This experimental study on dogs was carried out to investigate the potential drug interaction between pindolol [Visken] as peta blocker with intrinsic sympathomimetic activity and enflurane as general anaesthestic. The results showed the lack of adverse interaction between pindolol with its intrinsic sympathomimetic activity and engurane anaeathesia as regard the heart rate and th1 mean arterial blood pressure, suggesting that th1 partial agonist activity of pindolol may be safer to be used under general anaesthlsis