RESUMO
Thalassemia, a heterogeneous disease, is one of the most common single-gene diseases worldwide. The aim of this study was to find associations between hematological indices and severity of beta-globin gene mutations in beta-thalassemia carriers. In this cross-sectional study, 30 beta-goblin gene mutations [beta[+] and beta°] in 1206 unrelated beta-thalassemia carriers were investigated. In addition, their hematological indices, including CBC and electrophoresis results, were determined. The association between genetic findings and hematological parameters [mean corpuscular volume [MCV] and mean hematocrit corpuscular hematocrit [MCH]] were determined using the SPSS software, the statistical test being the t-test. The results indicated that beta[+]-thalassemia carriers had higher MCV and MCH means than beta°-thalassemia carriers. These findings would certainly have practical implications in public health. The results show a significant correlation between two hematological indices and certain types of mutations in beta-thalassemia carriers
RESUMO
While public focus is on the risks of transfusion transmitted infections, transfusion errors contribute significantly to adverse reactions. In this study we describe two cases of mistransfusion; two thalassemic siblings were admitted for monthly transfusion: a 19 year old boy and his sister. The donor whose blood donation was cross matched for the sister had a name similar to the brother; so it was wrongly administered to him that led to the hemolytic reaction. Another 2.5 year old boy with O[+] blood group received A[+] blood because of the staff error in recording the patient blood group and neglecting the crossmatch. The most prevalant complications of blood transfusion are due to human error. In order to decrease errors, it is recommended to double check the blood order form and the information on the blood bag