Elevated levels of plasma and platelet PAI-1 in type II diabetes: relationships with plasma insulin and lipoproteins

This study aimed to measure both plasma and platelet PAI-1 in type II diabetes and to investigate the relationship between PAI-1 levels and plasma insulin and lipoproteins. The data obtained suggested that higher level of platelet PAI-1 may contribute to impaired fibrinolysis seen in type II diabetes. Concordant increase of platelet PAI-1 and plasma insulin suggested that hyperinsulinemia presents in type II diabetes may have direct effects on the synthesis of platelet PAI-1