RESUMO
19 cases of osteosarcoma of stage 1113 were treated at Orthopaedic department, Lyari General Hospital and Civil Hospital, Karachi. The Neo adjuvant and adjuvant therapy were done by the different techniques i.e. custom made prosthesis, free fibular graft, fibular centraliziation, segment transportation, or tumor excision and Rotation plasty. There were 17 males and 2 females. Ranged from 10 years to 25 years, mean age was 18 years. The follow up period was from 13 months to 75 months and the mean period was 27 months. One case was lost to follow up. In the end of study there were 11 cases [61.11%] disease free survival, 3 [16.67%] survival with disease and 4[22.2%] died due to tumor. The disease free cases had mean 42.5 months of survival. It was concluded that males were 8 times more affected than the females. It was further observed that the treatment of choice for osteosarcoma is limb salvage. It was further observed that the limb salvage surgery along with pre operative chemotherapy, radiotherapy and postoperative chemotherapy has revolutionized the treatment out come of osteosarcoma. This treatment is more effective in terms of functional, cosmetic and emotional outcome