Topical metronidazole for severe and resistant cases of rosacea

Topical metronidazole 0.75% aqueous gel twice daily for 8 weeks was tried in 22 patients with either severe or resistant acne rosacea. Assessment of each case using investigator global assessment, scores for edema and erythema and number of inflammatory lesions was done before treatment and after 4 and 8 weeks of therapy. While, 18 out of 22 patients [81.8%] showed marked improvement, 2 patients [9.1%] were unchanged, and another 2 cases [9.1%] have got worse at the end of the 8 weeks. The drug was found to be tolerable and safe to all patients

Clinico-pathological study of onychomycosis

This study was carried out on 25 patients diagnosed clinically as onychomycosis to define the commonest fungi, and to detect the structural changes occurring in the affected nails. There was a marked pre-ponderance of moulds over dermatophytes in toe-nail infection than finger nails, while all candidal onychomycosis occurred in finger nails. Both hyphae and the arthrospores could be found easily in the fungus infected nails. The fungi penetrated the cornified cells forming irregular ragged passages. The structure of the nail plate was disturbed showing subungual hyperkeratosis and formation of deep processes containing fungi extending into the underlying tissue